Apolipoprotein B/apolipoprotein A-I in relation to the metabolic syndrome and change in carotid artery intima-media thickness during 3 years in middle-aged men

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: id:"swepub:oai:gup.ub.gu.se/49901" > Apolipoprotein B/ap...

1 av 1
Föregående post
Nästa post
Till träfflistan

Wallenfeldt, Karin,1960Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Wallenberg Laboratory,Institute of Internal Medicine, Dept of Medicine (författare)

Apolipoprotein B/apolipoprotein A-I in relation to the metabolic syndrome and change in carotid artery intima-media thickness during 3 years in middle-aged men

Artikel/kapitelEngelska2004

Förlag, utgivningsår, omfång ...

2004

Nummerbeteckningar

LIBRIS-ID:oai:gup.ub.gu.se/49901
https://gup.ub.gu.se/publication/49901URI

Kompletterande språkuppgifter

Språk:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

BACKGROUND AND PURPOSE: The apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio is a measure of the relationship between different lipoprotein particles and a powerful predictor of coronary death. The aim was to examine whether apoB/apoA-I was associated with the metabolic syndrome (MetS) at baseline and also with the future change in carotid artery intima-media thickness (IMT). METHODS: In 313 58-year-old men, carotid artery IMT was measured bilaterally by high-resolution B-mode ultrasound at baseline and after 3 years of follow-up. Serum apolipoprotein concentrations and the components of MetS were measured at study entry. RESULTS: ApoB/apoA-I showed statistically significant associations with body mass index, waist-to-hip ratio, high-density lipoprotein (HDL) cholesterol, triglycerides, low-density lipoprotein (LDL) particle size, insulin, and diastolic blood pressure. Two thirds of the patients with MetS had high apoB/apoA-I ratios (>0.90) compared with one third of those without the syndrome (P<0.001). The IMT change was associated with apoB, total cholesterol, LDL cholesterol, triglycerides, and inversely with HDL cholesterol and LDL particle size at entry, and there was a strong colinearity between these variables. The subjects with apoB/apoA-I above the first tertile (0.74) had a 20-microm-higher (95% CI, 7 to 33) annual increase in IMT compared with those below this level after adjustment for blood pressure and smoking. CONCLUSIONS: The apoB/apoA-I ratio was strongly associated with MetS and its components at baseline. ApoB/apoA-I at baseline was related to the change in carotid artery IMT during 3 years of follow-up. There was a strong colinearity between apoB/apoA and the atherogenic lipids.

Ämnesord och genrebeteckningar

Apolipoprotein A-I/*blood
Apolipoproteins B/*blood
Arteriosclerosis/blood
Body Mass Index
Carotid Arteries/*pathology/ultrasonography
Humans
Lipoproteins/blood
Male
Metabolic Syndrome X/*blood
Middle Aged
Obesity/*blood
Tunica Intima/*pathology/ultrasonography
Waist-Hip Ratio

Biuppslag (personer, institutioner, konferenser, titlar ...)

Bokemark, Lena,1960Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Wallenberg Laboratory,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xbokle (författare)
Wikstrand, John,1938Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Wallenberglaboratoriet,Cardiovascular Institute,Wallenberg Laboratory(Swepub:gu)xwikjo (författare)
Hulthe, Johannes,1970Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xhultj (författare)
Fagerberg, Björn,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Wallenberglaboratoriet,Institute of Internal Medicine, Dept of Medicine,Wallenberg Laboratory(Swepub:gu)xfagbj (författare)
Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Sammanhörande titlar

Ingår i:Stroke35:10, s. 2248-521524-4628

Internetlänk

https://gup.ub.gu.se/publication/49901

Hitta via bibliotek

Stroke (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Wallenfeldt, Kar ...; Bokemark, Lena, ...; Wikstrand, John, ...; Hulthe, Johannes ...; Fagerberg, Björn ...

Artiklar i publikationen: Stroke

Av lärosätet: Göteborgs universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se