id:"swepub:oai:gup.ub.gu.se/50280"
Sökning: id:"swepub:oai:gup.ub.gu.se/50280" > Tissue-specific tar...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Beck, Caroline,1976Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (författare)
Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future challenges
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
- 2004
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/50280
- https://gup.ub.gu.se/publication/50280URI
Kompletterande språkuppgifter
- Språk:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- The introduction of genes to cardiovascular cells in vivo remains the major challenge for current gene therapy modalities. However, recent developments in retargeting adenoviral vectors are promising to improve transduction efficiency in the cardiovascular cells. After systemic application, most adenoviral vectors are trapped by the liver, hampering delivery to target cardiovascular tissues. Furthermore, a majority of vectors for vascular gene transfer utilizes strong heterologous viral promoters, such as CMV. A potential side effect related to the use of such vectors is the systemic organ toxicity resulting from unrestricted transgene expression. These vectors have the additional problem of being frequently shut-down in vivo. Therefore, both retargeting adenoviral vectors and the use of tissue-specific promoter-driven vectors offer an enhanced safety profile by reducing ectopic expression in vital organs including the liver and lung. However, the limiting factor for the use of tissue-specific promoters is the low-level of expression compared with their viral counterparts. Both the development of efficient and strong vectors using cell-specific regulatory elements and the production of therapeutic proteins at sufficient levels is urgently needed to inhibit vasculoproliferative disorders. This review will focus on some of the recent achievements in vector development relevant to the delivery of vascular gene therapies targeted to the vascular endothelium, smooth muscle cells and macrophages during arterial remodelling.
Ämnesord och genrebeteckningar
- Adenoviridae/genetics
- Animals
- Cardiovascular System/*metabolism
- Endothelium
- Vascular/metabolism
- Gene Expression
- Gene Therapy/*methods/trends
- Gene Transfer Techniques
- Genetic Engineering
- *Genetic Vectors
- Humans
- Macrophages/metabolism
- Muscle
- Smooth
- Vascular/metabolism
- Organ Specificity
- Promoter Regions (Genetics)
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Uramoto, Hidetaka (författare)
- Borén, Jan,1963Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xborej (författare)
- Akyürek, Levent,1966Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för anatomi och cellbiologi,Wallenberg Laboratory,Institute of Anatomy and Cell Biology(Swepub:gu)xakyle (författare)
- Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Current Gene Therapies4:4, s. 457-671566-5232
Internetlänk
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Beck, Caroline, ...
- Uramoto, Hidetak ...
- Borén, Jan, 1963
- Akyürek, Levent, ...
- Artiklar i publikationen
- Current Gene The ...
- Av lärosätet
- Göteborgs universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
