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A new combined mult...
A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions
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- Adiels, Martin, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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Packard, C. (författare)
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Caslake, M. J. (författare)
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Stewart, P. (författare)
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Soro, A. (författare)
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Westerbacka, J. (författare)
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- Wennberg, Bernt, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Olofsson, Sven-Olof, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg
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Taskinen, M. R. (författare)
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- Borén, Jan, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: J Lipid Res. - 0022-2275 .- 1539-7262. ; 46:1, s. 58-67
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- The use of stable isotopes in conjunction with compartmental modeling analysis has greatly facilitated studies of the metabolism of the apolipoprotein B (apoB)-containing lipoproteins in humans. The aim of this study was to develop a multicompartment model that allows us to simultaneously determine the kinetics of apoB and triglyceride (TG) in VLDL(1) and VLDL(2) after a bolus injection of [(2)H(3)]leucine and [(2)H(5)]glycerol and to follow the catabolism and transfer of the lipoprotein particles. Here, we describe the model and present the results of its application in a fasting steady-state situation in 17 subjects with lipid values representative of a Western population. Analysis of the correlations showed that plasma TG was determined by the VLDL(1) and VLDL(2) apoB and TG fractional catabolic rate. Furthermore, the model showed a linear correlation between VLDL(1) TG and apoB production. A novel observation was that VLDL TG entered the circulation within 21 min after its synthesis, whereas VLDL apoB entered the circulation after 33 min. These observations are consistent with a sequential assembly model of VLDL and suggest that the TG is added to a primordial apoB-containing particle in the liver.
Nyckelord
- Apolipoprotein B-100
- Apolipoproteins B/biosynthesis/*metabolism
- Deuterium/administration & dosage/metabolism
- Glycerol/administration & dosage/metabolism
- Humans
- Kinetics
- Leucine/administration & dosage/metabolism
- Lipoproteins
- VLDL/biosynthesis/*metabolism
- Models
- Biological
- Protein Transport
- Triglycerides/biosynthesis/*metabolism
- Triglycerides/biosynthesis/*metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Adiels, Martin, ...
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Packard, C.
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Caslake, M. J.
-
Stewart, P.
-
Soro, A.
-
Westerbacka, J.
-
visa fler...
-
Wennberg, Bernt, ...
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Olofsson, Sven-O ...
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Taskinen, M. R.
-
Borén, Jan, 1963
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visa färre...
- Artiklar i publikationen
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J Lipid Res
- Av lärosätet
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Göteborgs universitet
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Chalmers tekniska högskola