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Overproduction of l...
Overproduction of large VLDL particles is driven by increased liver fat content in man
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- Adiels, Martin, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg
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Taskinen, M. R. (författare)
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Packard, C. (författare)
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Caslake, M. J. (författare)
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Soro-Paavonen, A. (författare)
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Westerbacka, J. (författare)
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Vehkavaara, S. (författare)
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Hakkinen, A. (författare)
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- Olofsson, Sven-Olof, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg
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Yki-Jarvinen, H. (författare)
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- Borén, Jan, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,University of Gothenburg
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(creator_code:org_t)
- 2006-02-04
- 2006
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 49:4, s. 755-65
- Relaterad länk:
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https://link.springe...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- AIMS/HYPOTHESIS: We determined whether hepatic fat content and plasma adiponectin concentration regulate VLDL(1) production. METHODS: A multicompartment model was used to simultaneously determine the kinetic parameters of triglycerides (TGs) and apolipoprotein B (ApoB) in VLDL(1) and VLDL(2) after a bolus of [(2)H(3)]leucine and [(2)H(5)]glycerol in ten men with type 2 diabetes and in 18 non-diabetic men. Liver fat content was determined by proton spectroscopy and intra-abdominal fat content by MRI. RESULTS: Univariate regression analysis showed that liver fat content, intra-abdominal fat volume, plasma glucose, insulin and HOMA-IR (homeostasis model assessment of insulin resistance) correlated with VLDL(1) TG and ApoB production. However, only liver fat and plasma glucose were significant in multiple regression models, emphasising the critical role of substrate fluxes and lipid availability in the liver as the driving force for overproduction of VLDL(1) in subjects with type 2 diabetes. Despite negative correlations with fasting TG levels, liver fat content, and VLDL(1) TG and ApoB pool sizes, adiponectin was not linked to VLDL(1) TG or ApoB production and thus was not a predictor of VLDL(1) production. However, adiponectin correlated negatively with the removal rates of VLDL(1) TG and ApoB. CONCLUSIONS/INTERPRETATION: We propose that the metabolic effect of insulin resistance, partly mediated by depressed plasma adiponectin levels, increases fatty acid flux from adipose tissue to the liver and induces the accumulation of fat in the liver. Elevated plasma glucose can further increase hepatic fat content through multiple pathways, resulting in overproduction of VLDL(1) particles and leading to the characteristic dyslipidaemia associated with type 2 diabetes.
Nyckelord
- Adipose Tissue/*metabolism/*pathology
- Adult
- Aged
- Apolipoproteins B/metabolism
- Diabetes Mellitus
- Type 2/metabolism/pathology
- Fatty Liver/*metabolism/*pathology
- Humans
- Lipoproteins
- VLDL/*biosynthesis/blood
- Male
- Middle Aged
- Lipoproteins
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Adiels, Martin, ...
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Taskinen, M. R.
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Packard, C.
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Caslake, M. J.
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Soro-Paavonen, A ...
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Westerbacka, J.
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visa fler...
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Vehkavaara, S.
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Hakkinen, A.
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Olofsson, Sven-O ...
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Yki-Jarvinen, H.
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Borén, Jan, 1963
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visa färre...
- Artiklar i publikationen
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Diabetologia
- Av lärosätet
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Göteborgs universitet
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Chalmers tekniska högskola