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Fibrous capsule for...
Fibrous capsule formation around titanium and copper.
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- Suska, Felicia, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Dept. of Biomaterials, Institute of Surgical Sciences Sahlgrenska Academy at Göteborg University
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- Emanuelsson, Lena, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Dept. of Biomaterials, Institute of Surgical Sciences, Sahlgrenska Academy at Göteborg University
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- Johansson, Anna, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Dept. of Biomaterials, Institute of Surgical Sciences, Sahlgrenska Academy at Göteborg University
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- Tengvall, Pentti (author)
- Linköpings universitet,Tekniska högskolan,Tillämpad Fysik
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- Thomsen, Peter, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences,Institute of Clinical Sciences, Department of Biomaterials,Dept. of Biomaterials, Institute of Surgical Sciences, Sahlgrenska Academy at Göteborg University
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Journal of Biomedical Materials Research Part A. - : Wiley. - 1549-3296 .- 1552-4965 .- 0021-9304 .- 1097-4636. ; 85:4, s. 888-96
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Previous studies suggest that implant material properties influence the quality and quantity of fibrous capsule around the implant. However, the precise relation between material surface chemistry, early inflammatory response, and fibrous subsequent repair outcome is still unknown. Titanium (Ti) and copper (Cu), surfaces with different inflammatory potential, were implanted subcutaneously in rats and retrieved fibrous capsules were analyzed after 28 and 56 days. Histological examinations show pronounced differences in capsule morphology. The fibrous capsule around Ti was thinner than that around Cu, with less number of the inflammatory cells in the layer close to the implant surface, and less and smaller blood vessels. The capsule around Cu was thick, with a large number of the inflammatory cells, particularly macrophages and giant cells, and increased number of blood vessels. Our study suggests that material surface properties, which initiate early, multiple cellular inflammatory events, are also associated with increased fibrosis and angiogenesis during repair phase. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- inflammation
- fibrosis
- angiogenesis
- titanium
- copper
- NATURAL SCIENCES
Publication and Content Type
- ref (subject category)
- art (subject category)
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