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Tracheal double-lum...
Tracheal double-lumen ventilation attenuates hypercapnia and respiratory acidosis in lung injured pigs.
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- Lethvall, Sven, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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- Lindgren, Sophie, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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- Lundin, Stefan, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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- Stenqvist, Ola, 1944 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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(creator_code:org_t)
- 2004-03-04
- 2004
- Engelska.
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Ingår i: Intensive care medicine. - : Springer Science and Business Media LLC. - 0342-4642 .- 1432-1238. ; 30:4, s. 686-92
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Evaluation of ventilatory and circulatory effects with coaxial double-lumen tube ventilation for dead-space reduction as compared with standard endotracheal tube ventilation. DESIGN: Experimental study in a pig model of lung lavage induced acute lung injury. SETTING: University research laboratory. MEASUREMENTS AND RESULTS: Tidal volumes of 6, 8 and 10 ml/kg body weight with a set respiratory rate of 20 breaths per minute were used in a random order with both double-lumen ventilation and standard endotracheal tube ventilation. Measurements of ventilatory and circulatory parameters were obtained after steady state at each experimental stage. With a tidal volume of 6 ml/kg, PaCO(2) was reduced from 10.9 kPa (95% CI 9.0-12.9) with a standard endotracheal tube to 8.2 kPa (95% CI 7.0-9.4) with double-lumen ventilation. This corresponds to a reduction in carbon dioxide levels by 25%. At 6 ml/kg, pH increased from 7.17 (95% CI 7.09-7.24) with a standard endotracheal tube to 7.27 (95% CI 7.21-7.32) with double-lumen ventilation. Tracheal pressure was monitored continuously and no difference between single- or double-lumen ventilation was noted at corresponding levels of ventilation. There was no formation of auto-PEEP. Partial tube obstruction due to secretions was not observed during the experiments. CONCLUSIONS: Coaxial double-lumen tube ventilation is an effective adjunct to reduce technical dead space. It attenuates hypercapnia and respiratory acidosis in a lung injury pig model.
Nyckelord
- Acidosis
- Respiratory
- metabolism
- prevention & control
- Airway Resistance
- Animals
- Carbon Dioxide
- metabolism
- Central Venous Pressure
- physiology
- Disease Models
- Animal
- Female
- Hypercapnia
- metabolism
- prevention & control
- Male
- Pulmonary Gas Exchange
- physiology
- Random Allocation
- Respiration
- Artificial
- methods
- Respiratory Dead Space
- physiology
- Respiratory Distress Syndrome
- Adult
- chemically induced
- physiopathology
- Swine
- Trachea
- physiopathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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