id:"swepub:oai:gup.ub.gu.se/51438"
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- Järnum, SofiaLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine (author)
LEPREL1, a novel ER and Golgi resident member of the Leprecan family.
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- Elsevier BV,2004
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/51438
- https://gup.ub.gu.se/publication/51438URI
- https://doi.org/10.1016/j.bbrc.2004.03.060DOI
- https://lup.lub.lu.se/record/122858URI
Supplementary language notes
- Language:English
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Notes
- We have identified a novel protein, Leprecan-like 1 (LEPREL1), with profound similarity to the Leprecan family of proteoglycans. The genomic organization of the Leprecan gene family was found to be highly conserved. Expression analysis shows that LEPREL1 is expressed in most tissues as a 3.4 kb transcript encoding an 80 kDa protein. A LEPREL1 specific antibody stains many cell types including adipocytes and neuroendocrine cells of the gastrointestinal epithelium. Muscle tissue contains a specific 6.5 kb transcript and a 200 kDa protein. The 3.4 kb LEPREL1 transcript encodes a 708 amino acid protein containing a signal sequence, four tetratricopeptide repeats (TPRs), a leucine zipper, a P-loop, a prolyl 4-hydroxylase alpha domain (P4Halpha), and a C-terminal KDEL ER-retention motif. LEPREL1 is localized to the ER and Golgi network and over-expressing it affects normal protein disulfide isomerase staining patterns in the ER.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- Amino Acid Sequence
- Animals
- Cell Line
- Tumor
- Endoplasmic Reticulum
- metabolism
- ultrastructure
- Fibrosarcoma
- genetics
- metabolism
- Golgi Apparatus
- metabolism
- ultrastructure
- Humans
- Membrane Glycoproteins
- chemistry
- genetics
- metabolism
- Mice
- Molecular Sequence Data
- Organ Specificity
- Proteoglycans
- chemistry
- genetics
- metabolism
- Sequence Analysis
- Protein
- Sequence Homology
- Amino Acid
- Species Specificity
- Tissue Distribution
- Hydroxylase
- TPR
- Author Keywords: Protein disulfide isomerase
- P4Hα
- Liposarcoma
Added entries (persons, corporate bodies, meetings, titles ...)
- Kjellman, ChristianLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)wbl-ckj (author)
- Darabi, AnnaLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)wbl-ajo (author)
- Nilsson, IngarLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Utvecklings- och regenerativ neurobiologi,Molecular Neurogenetics,Lund University Research Groups,Developmental and Regenerative Neurobiology(Swepub:lu)wbl-ini (author)
- Edvardsen, KlausLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)wbl-ked (author)
- Åman, Pierre,1953Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology(Swepub:gu)xamapi (author)
- Institutionen för experimentell medicinsk vetenskapMedicinska fakulteten (creator_code:org_t)
Related titles
- In:Biochemical and biophysical research communications: Elsevier BV317:2, s. 342-510006-291X1090-2104
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