The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers

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MARC

Björk-Eriksson, Thomas,1960Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology (author)

The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers

Article/chapterEnglish1999

Publisher, publication year, extent ...

1999

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LIBRIS-ID:oai:gup.ub.gu.se/52272
https://gup.ub.gu.se/publication/52272URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

A study was made of the relationship between measurements of radiosensitivity versus proliferation and p53 status in head and neck cancers. Inherent tumour radiosensitivity was assessed as surviving fraction at 2 Gy (SF2) using a clonogenic soft agar assay (n = 77). The results were compared to data on proliferation obtained by both flow cytometry (labelling index (LI), the potential doubling time (Tpot) n = 55) and immunohistochemistry (Ki-67 and PCNA; n = 68), together with immunohistochemical p53 expression (n = 68). There were no overall significant differences in the median values of the various parameters analysed for the different sites within the head and neck region, disease stages, grades of tumour differentiation or nodal states. A subgroup analysis showed that oropharyngeal (n = 22) versus oral cavity (n = 35) tumours were more radiosensitive (P = 0.056) and had a higher Ki-67 index (P = 0.001). Node-positive tumours had higher LI (P = 0.021) and a trend towards lower Tpot (P = 0.067) values than node-negative ones. No correlations were seen between SF2 and any of the parameters studied. The long-standing dogma of an increased radiosensitivity of rapidly proliferating cells in contrast to slowly proliferating cells was not confirmed. The study shows that parallel measurements of different biological markers can be obtained for a large number of patients with head and neck cancers. The independence of the various parameters studied suggests that there may be potential for their combined use as prognostic factors for the outcome of radiotherapy.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Adult
Aged
Aged
80 and over
Cell Division
DNA/biosynthesis
Female
Head and Neck Neoplasms/pathology/*radiotherapy
Humans
Ki-67 Antigen/*analysis
Male
Middle Aged
Proliferating Cell Nuclear Antigen/*analysis
*Radiation Tolerance
Tumor Suppressor Protein p53/*analysis

Added entries (persons, corporate bodies, meetings, titles ...)

West, C. M. (author)
Cvetskovska, E. (author)
Svensson, M. (author)
Karlsson, E. (author)
Magnusson, B. (author)
Slevin, N. J. (author)
Edstrom, S. (author)
Mercke, Claes,1941Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology(Swepub:gu)xmercl (author)
Göteborgs universitetInstitutionen för särskilda specialiteter, Avdelningen för onkologi (creator_code:org_t)

Related titles

In:Br J Cancer80:9, s. 1400-40007-0920

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https://gup.ub.gu.se/publication/52272

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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