Candidate gene region 2q33 in European families with coeliac disease.

• Chromosome region 2q33 harbours a cluster of genes, CTLA-4, CD28, ICOS and closely located PD-1, all related to immune activation and considered as promising candidate genes for susceptibility to coeliac disease (CD). We present here the results of a genetic linkage and association analysis of nine markers located in this gene region in a large combined European material of 796 families with CD from Finland, Sweden, Norway, UK, France and Italy. The joint analysis supports earlier findings that this susceptibility locus, assigned as CELIAC3, merits further studies. Nominally significant linkage to CD was found in 314 families including affected sib pairs. Each of the five populations showed weak associations to several marker alleles, but the analysis revealed, however, no conclusive evidence for a primary functional gene or gene variant present in the total set of families. The results suggest that the CD risk due to 2q33 gene region is complex and may involve more than one susceptibility allele, which possibly differ from other autoimmune diseases.

Keyword

Alleles

Antigens

CD

Antigens

CD28

genetics

Antigens

Differentiation

genetics

Antigens

Differentiation

T-Lymphocyte

genetics

Antigens

Surface

genetics

Apoptosis Regulatory Proteins

Celiac Disease

genetics

Chromosome Mapping

Chromosomes

Human

Pair 2

genetics

Europe

European Continental Ancestry Group

genetics

Female

Gene Frequency

Genetic Markers

Genetic Predisposition to Disease

Haplotypes

genetics

Humans

Linkage (Genetics)

Male

Polymorphism

Genetic

Publication and Content Type

ref (subject category)

art (subject category)