Sökning: WFRF:(Konrad D)
> (2005-2009) >
Positive inotropic ...
Positive inotropic and negative lusitropic effects of endothelin receptor agonism in vivo.
-
- Konrad, D (författare)
- Karolinska Institutet
-
- Oldner, A (författare)
- Karolinska Institutet
-
- Wanecek, M (författare)
- Karolinska Institutet
-
visa fler...
-
- Rudehill, A (författare)
- Karolinska Institutet, Anestesiologi och Intensivvård, Stockholm
-
- Weitzberg, E (författare)
- Karolinska Institutet
-
- Biber, Björn, 1944 (författare)
- Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care,Anestesiologi och intensivvård
-
- Johansson, Göran (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
- Häggmark, Sören (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
- Haney, Michael (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
visa färre...
-
(creator_code:org_t)
- American Physiological Society, 2005
- 2005
- Engelska.
-
Ingår i: Am J Physiol Heart Circ Physiol. - : American Physiological Society. - 0363-6135 .- 1522-1539. ; 289:4
- Relaterad länk:
-
http://umu.diva-port...
-
visa fler...
-
http://www.ncbi.nlm....
-
https://umu.diva-por... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The endothelin (ET) system is involved in the regulation of myocardial function in health as well as in several diseases, such as congestive heart failure, myocardial infarction, and septic myocardial depression. Conflicting results have been reported regarding the acute contractile properties of ET-1. We therefore investigated the effects of intracoronary infusions of ET-1 and of the selective ET(B) receptor-selective agonist sarafotoxin 6c with increasing doses in anesthetized pigs. Myocardial effects were measured through analysis of the left ventricular pressure-volume relationship. ET-1 elicited increases in the myocardial contractile status (end-systolic elastance value of 0.94 +/- 0.11 to 1.48 +/- 0.23 and preload recruitable stroke work value of 68.7 +/- 4.7 to 83.4 +/- 7.2) that appear to be mediated through ET(A) receptors, whereas impairment in left ventricular isovolumic relaxation (tau = 41.5 +/- 1.4 to 58.1 +/- 5.0 and t(1/2) = 23.0 +/- 0.7 to 30.9 +/- 2.6, where tau is the time constant for pressure decay and t(1/2) is the half-time for pressure decay) was ET(B) receptor dependent. In addition, intravenous administration of ET-1 impaired ventricular relaxation but had no effect on contractility. Intracoronary sarafotoxin 6c administration caused impairments in left ventricular relaxation (tau from 43.3 +/- 1.8 to 54.4 +/- 3.4) as well as coronary vasoconstriction. In conclusion, ET-1 elicits positive inotropic and negative lusitropic myocardial effects in a pig model, possibly resulting from ET(A) and ET(B) receptor activation, respectively.
Nyckelord
- Anesthesia
- Animals
- Cardiotonic Agents
- pharmacology
- Coronary Circulation
- drug effects
- Diastole
- drug effects
- Endothelin-1
- blood
- pharmacology
- Female
- Heart
- drug effects
- physiology
- Injections
- Intravenous
- Myocardial Contraction
- drug effects
- Oxygen
- metabolism
- Receptor
- Endothelin B
- antagonists & inhibitors
- Receptors
- Endothelin
- agonists
- Sus scrofa
- Vasoconstrictor Agents
- pharmacology
- Ventricular Pressure
- drug effects
- Viper Venoms
- pharmacology
- Anesthesia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Konrad, D
-
Oldner, A
-
Wanecek, M
-
Rudehill, A
-
Weitzberg, E
-
Biber, Björn, 19 ...
-
visa fler...
-
Johansson, Göran
-
Häggmark, Sören
-
Haney, Michael
-
visa färre...
- Artiklar i publikationen
-
Am J Physiol Hea ...
-
American Journal ...
- Av lärosätet
-
Göteborgs universitet
-
Umeå universitet
-
Karolinska Institutet