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  • Rao, Malla (författare)

Serologic correlates of protection against enterotoxigenic Escherichia coli diarrhea

  • Artikel/kapitelEngelska2005

Förlag, utgivningsår, omfång ...

  • 2005

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/52691
  • https://gup.ub.gu.se/publication/52691URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: We conducted a nested case-control study in 397 rural Egyptian children <36 months of age to assess the correlation between serum levels of antibodies against toxin and colonization factors (CFs) and the risk of homologous enterotoxigenic Escherichia coli (ETEC) diarrhea. METHODS: Active case detection was performed via semiweekly home visits, and blood was obtained at 3-month intervals. After each serosurvey, case subjects were selected from children experiencing a CF antigen (CFA)/I-, CFA/II-, CFA/IV-, or heat-labile enterotoxin (LT)-ETEC diarrheal episode during the subsequent 3 months. Up to 5 control subjects per case subject were selected from children who did not experience an ETEC diarrheal episode during the corresponding interval. Serum titers of immunoglobulin G antibodies against CFA/I, coli surface antigen (CS) 3, CS6, and LT were measured by enzyme-linked immunosorbant assay. RESULTS: The distribution of serum titers of LT, CS3, and CS6 antibodies did not differ between the case and control subjects. For children <18 months of age, serum titers of CFA/I antibody were inversely related to the risk of CFA/I-ETEC diarrhea; reciprocal serum titers of CFA/I antibody > or =76 were associated with a 77% reduction in the odds of CFA/I-ETEC diarrhea. CONCLUSION: Induction of reciprocal serum titers of antibodies against CFA/I within or above the 76-186 range should be further evaluated as a predictor for assessment of the ability of candidate vaccines to protect against CFA/I-ETEC diarrhea.

Ämnesord och genrebeteckningar

  • Antibodies
  • Bacterial/*blood
  • Bacterial Proteins/analysis/immunology
  • Bacterial Toxins/analysis/*immunology
  • Case-Control Studies
  • Child
  • Preschool
  • Diarrhea/*microbiology/*prevention & control
  • Egypt
  • Enterotoxins/analysis/*immunology
  • Enzyme-Linked Immunosorbent Assay
  • Escherichia coli/*immunology/pathogenicity
  • Escherichia coli Infections/*immunology/microbiology
  • Escherichia coli Proteins/analysis/*immunology
  • Female
  • Fimbriae Proteins/analysis/immunology
  • Humans
  • Immunoglobulin G/blood
  • Infant
  • Male
  • Virulence Factors/analysis/immunology

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wierzba, Thomas (författare)
  • Savarino, Stephen (författare)
  • Abu-Elyazeed, Remon (författare)
  • El-Ghoreb, N. (författare)
  • Hall, E. R. (författare)
  • Naficy, Abdollah (författare)
  • Abdel-Messih, I. (författare)
  • Frenck, Robert W Jr (författare)
  • Svennerholm, Ann-Mari,1947Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology(Swepub:gu)xsannx (författare)
  • Clemens, JohnGothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology (författare)
  • Göteborgs universitetInstitutionen för medicinsk mikrobiologi och immunologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:J Infect Dis191:4, s. 562-70

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