Sökning: WFRF:(Naficy Abdollah) >
Serologic correlate...
Serologic correlates of protection against enterotoxigenic Escherichia coli diarrhea
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:gup.ub.gu.se/52691
-
https://gup.ub.gu.se/publication/52691URI
Kompletterande språkuppgifter
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
BACKGROUND: We conducted a nested case-control study in 397 rural Egyptian children <36 months of age to assess the correlation between serum levels of antibodies against toxin and colonization factors (CFs) and the risk of homologous enterotoxigenic Escherichia coli (ETEC) diarrhea. METHODS: Active case detection was performed via semiweekly home visits, and blood was obtained at 3-month intervals. After each serosurvey, case subjects were selected from children experiencing a CF antigen (CFA)/I-, CFA/II-, CFA/IV-, or heat-labile enterotoxin (LT)-ETEC diarrheal episode during the subsequent 3 months. Up to 5 control subjects per case subject were selected from children who did not experience an ETEC diarrheal episode during the corresponding interval. Serum titers of immunoglobulin G antibodies against CFA/I, coli surface antigen (CS) 3, CS6, and LT were measured by enzyme-linked immunosorbant assay. RESULTS: The distribution of serum titers of LT, CS3, and CS6 antibodies did not differ between the case and control subjects. For children <18 months of age, serum titers of CFA/I antibody were inversely related to the risk of CFA/I-ETEC diarrhea; reciprocal serum titers of CFA/I antibody > or =76 were associated with a 77% reduction in the odds of CFA/I-ETEC diarrhea. CONCLUSION: Induction of reciprocal serum titers of antibodies against CFA/I within or above the 76-186 range should be further evaluated as a predictor for assessment of the ability of candidate vaccines to protect against CFA/I-ETEC diarrhea.
Ämnesord och genrebeteckningar
-
Antibodies
-
Bacterial/*blood
-
Bacterial Proteins/analysis/immunology
-
Bacterial Toxins/analysis/*immunology
-
Case-Control Studies
-
Child
-
Preschool
-
Diarrhea/*microbiology/*prevention & control
-
Egypt
-
Enterotoxins/analysis/*immunology
-
Enzyme-Linked Immunosorbent Assay
-
Escherichia coli/*immunology/pathogenicity
-
Escherichia coli Infections/*immunology/microbiology
-
Escherichia coli Proteins/analysis/*immunology
-
Female
-
Fimbriae Proteins/analysis/immunology
-
Humans
-
Immunoglobulin G/blood
-
Infant
-
Male
-
Virulence Factors/analysis/immunology
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Wierzba, Thomas
(författare)
-
Savarino, Stephen
(författare)
-
Abu-Elyazeed, Remon
(författare)
-
El-Ghoreb, N.
(författare)
-
Hall, E. R.
(författare)
-
Naficy, Abdollah
(författare)
-
Abdel-Messih, I.
(författare)
-
Frenck, Robert W Jr
(författare)
-
Svennerholm, Ann-Mari,1947Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology(Swepub:gu)xsannx
(författare)
-
Clemens, JohnGothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
(författare)
-
Göteborgs universitetInstitutionen för medicinsk mikrobiologi och immunologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:J Infect Dis191:4, s. 562-70
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Rao, Malla
-
Wierzba, Thomas
-
Savarino, Stephe ...
-
Abu-Elyazeed, Re ...
-
El-Ghoreb, N.
-
Hall, E. R.
-
visa fler...
-
Naficy, Abdollah
-
Abdel-Messih, I.
-
Frenck, Robert W ...
-
Svennerholm, Ann ...
-
Clemens, John
-
visa färre...
- Artiklar i publikationen
- J Infect Dis
- Av lärosätet
-
Göteborgs universitet