(WFRF:(Rosengren Annika 1951 ))
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- Dotevall, Annika,1957Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine (författare)
Diabetes mellitus: clinical presentation and outcome in men and women with acute coronary syndromes. Data from the Euro Heart Survey ACS
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
- 2005
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/52715
- https://gup.ub.gu.se/publication/52715URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-78101URI
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- Språk:engelska
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- AIMS: To study clinical presentation, in-hospital course and short-term prognosis in men and women with diabetes mellitus and acute coronary syndromes (ACS). METHODS: Men (n = 6488, 21.2% with diabetes) and 2809 women (28.7% with diabetes) < or = 80 years old, with a discharge diagnosis of ACS were prospectively enrolled in the Euro Heart Survey of ACS. RESULTS: Women with diabetes were more likely to present with ST elevation than non-diabetic women, a difference that became more marked after adjustment for differences in smoking, hypertension, obesity, medication and prior disease [adjusted odds ratio (OR) 1.46 (1.20, 1.78)], whereas there was little difference between diabetic and non-diabetic men [adjusted OR 0.99 (0.86, 1.14)]. In addition, women with diabetes were more likely to develop Q-wave myocardial infarction (MI) than non-diabetic women [adjusted OR 1.61 (1.30, 1.99)], while there was no difference between men with and without diabetes [adjusted OR 0.99 (0.85, 1.15)]. There were significant interactions between sex, diabetes and presenting with ST-elevation ACS (P < 0.001), and Q-wave MI (P < 0.001), respectively. Of the women with diabetes, 7.4% died in hospital, compared with 3.6% of non-diabetic women [adjusted OR 2.13 (1.39, 3.26)], whereas corresponding mortality rates in men with and without diabetes were 4.1% and 3.3%, respectively [OR 1.13 (0.76, 1.67)] (P for diabetes-sex interaction 0.021). CONCLUSION: In women with ACS, diabetes is associated with higher risk of presenting with ST-elevation ACS, developing Q-wave MI, and of in-hospital mortality, whereas in men with ACS diabetes is not significantly associated with increased risk of either. These findings suggest a differential effect of diabetes on the pathophysiology of ACS based on the patient's sex.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- Aged
- Coronary Disease/*epidemiology/therapy
- Diabetic Angiopathies/*epidemiology/therapy
- Female
- Humans
- Male
- Middle Aged
- Risk Factors
- Sex Factors
- Aged
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Hasdai, D. (författare)
- Wallentin, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larswall (författare)
- Battler, A. (författare)
- Rosengren, Annika,1951Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xrosan (författare)
- Göteborgs universitetInstitutionen för invärtesmedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Diabet Med22:11, s. 1542-500742-30711464-5491
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