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B cells pulsed with...
B cells pulsed with Helicobacter pylori antigen efficiently activate memory CD8+ T cells from H. pylori-infected individuals
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- Azem, Josef, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
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- Svennerholm, Ann-Mari, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
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- Lundin, Samuel B, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Clin Immunol. - : Elsevier BV. ; 118:2-3, s. 284-91
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Helicobacter pylori infection causes chronic gastritis that may progress to peptic ulcers or gastric adenocarcinoma and thereby cause major world-wide health problems. Previous studies have shown that CD4+ T cells are important in the immune response to H. pylori in humans, but the role of CD8+ T cells is less clear. In order to study the CD8+ T cell response to H. pylori in greater detail, we have evaluated efficient conditions for activation of CD8+ T cells in vitro. We show that H. pylori-reactive CD8+ T cells can be activated most efficiently by B cells or dendritic cells pulsed with H. pylori antigens. We further show that the majority of CD8+ T cells in H. pylori-infected gastric mucosa are memory cells, and that memory CD8+ T cells sorted from peripheral blood of H. pylori-infected individuals respond 15-fold more to H. pylori urease compared to memory cells from uninfected subjects. We conclude that CD8+ T cells do participate in the immune response to H. pylori, and this may have implications for the development of more severe disease outcomes in H. pylori-infected subjects.
Keyword
- Adult
- Antigens
- Bacterial/immunology/*physiology
- B-Lymphocyte Subsets/*immunology/*microbiology
- CD8-Positive T-Lymphocytes/*immunology
- Cell Proliferation
- Cells
- Cultured
- Gastric Mucosa/immunology/microbiology
- Helicobacter Infections/*immunology
- Helicobacter pylori/*immunology
- Humans
- *Immunologic Memory
- Middle Aged
- Monocytes/immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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