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Long-term results i...
Long-term results in children with AML: NOPHO-AML Study Group--report of three consecutive trials
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
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Springer Science and Business Media LLC,2005
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/53024
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https://gup.ub.gu.se/publication/53024URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1929137URI
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https://doi.org/10.1038/sj.leu.2403962DOI
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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In all, 447 children with acute myeloid leukaemia (AML) have been treated on three consecutive NOPHO studies from July 1984 to December 2001. NOPHO-AML 84 was of moderate intensity with an induction of three courses of cytarabine, 6-thioguanine and doxorubicin followed by four consolidation courses with high-dose cytarabine. The 5-year event-free survival (EFS), disease free survival (DFS) and overall survival (OS) were 29, 37 and 38%. NOPHO-AML 88 was of high intensity with the addition of etoposide and mitoxantrone in selected courses during induction and consolidation. The interval between the induction courses should be as short as possible, that is, time intensity was introduced. The 5-year EFS, DFS and OS were 41, 48 and 46%. In NOPHO-AML 93, the treatment was stratified according to response to first induction course. The protocol utilised the same induction blocks as NOPHO-AML 88, but after the first block, children with a hypoplastic, nonleukaemic bone marrow were allowed to recover before the second block. Consolidation was identical with NOPHO-AML 88. The 5-year EFS, DFS and OS in NOPHO-AML 93 were 48, 52 and 65%. The new NOPHO-AML protocol has been based on experiences from previous protocols with stratification of patients with regard to in vivo response and specific cytogenetic aberrations.
Ämnesord och genrebeteckningar
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Acute Disease
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Adolescent
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Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
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Antineoplastic Protocols/*standards
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Bone Marrow/drug effects
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Child
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Child
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Preschool
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Drug Administration Schedule
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Female
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Follow-Up Studies
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Humans
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Infant
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Infant
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Newborn
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Leukemia
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Myeloid/mortality/*therapy
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Male
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Remission Induction/methods
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Survival Analysis
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Treatment Outcome
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Abrahamsson, Jonas,1954Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics(Swepub:gu)xabrjo
(författare)
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Clausen, N.
(författare)
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Forestier, E.
(författare)
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Hasle, H.
(författare)
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Hovi, L.
(författare)
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Jonmundsson, G.
(författare)
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Mellander, Lotta,1941Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics(Swepub:gu)xmello
(författare)
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Siimes, M. A.
(författare)
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Yssing, M.
(författare)
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Zeller, B.
(författare)
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Gustafsson, G.Karolinska Institutet
(författare)
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Göteborgs universitetInstitutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Leukemia: Springer Science and Business Media LLC19:12, s. 2090-1000887-69241476-5551
Internetlänk
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Leukemia
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Till lärosätets databas
- Av författaren/redakt...
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Lie, S. O.
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Abrahamsson, Jon ...
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Clausen, N.
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Forestier, E.
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Hasle, H.
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Hovi, L.
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visa fler...
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Jonmundsson, G.
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Mellander, Lotta ...
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Siimes, M. A.
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Yssing, M.
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Zeller, B.
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Gustafsson, G.
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visa färre...
- Artiklar i publikationen
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Leukemia
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet