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Temporary preservat...
Temporary preservation of beta-cell function by diazoxide treatment in childhood type 1 diabetes
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- Ortqvist, E. (author)
- Karolinska Institutet,Astrid Lindgrens Barnsjukhus Stockholm
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- Björk, Elisabeth (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Medicinkliniken Akademiska sjukhuset, Uppsala
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- Wallensteen, M. (author)
- Astrid Lindgrens Barnsjukhus Stockholm
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- Ludvigsson, Johnny, 1943- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping
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- Aman, J. (author)
- Barnkliniken Universitetssjukhuset, Örebro
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- Johansson, C. (author)
- Barnkliniken Ryhovs sjukhus, Jönköping
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- Forsander, Gun, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Barnkliniken Lasarettet, Falun
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- Lindgren, F. (author)
- Sachsska Barnsjukhuset Stockholm
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- Berglund, Lars (author)
- Clinical Research Centre Uppsala Universitet
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- Bengtsson, Mats (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Klinisk Immunologi Uppsala Universitet
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- Berne, Christian (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Medicinkliniken Akademiska sjukhuset, Uppsala
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- Persson, B. (author)
- Astrid Lindgrens Barnsjukhus Stockholm
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- Karlsson, F. A. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Medicinkliniken Akademiska sjukhuset, Uppsala
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(creator_code:org_t)
- American Diabetes Association, 2004
- 2004
- English.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 27:9, s. 2191-7
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http://care.diabetes...
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https://doi.org/10.2...
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Abstract
Subject headings
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- OBJECTIVE: We examined the effect of diazoxide, an ATP-sensitive K(+) channel opener and inhibitor of insulin secretion, on beta-cell function and remission in children at clinical onset of type 1 diabetes. RESEARCH DESIGN AND METHODS: A total of 56 subjects (21 girls and 35 boys, age 7-17 years) were randomized to 3 months of active treatment (diazoxide 5-7.5 mg/kg in divided doses) or placebo in addition to multiple daily insulin injections and were followed for 2 years. RESULTS: Diazoxide decreased circulating C-peptide concentrations by approximately 50%. After cessation of the treatment, basal and meal-stimulated C-peptide concentrations increased to a maximum at 6 months, followed by a decline. Meal-stimulated C-peptide concentration was significantly higher at 12 months (0.43 +/- 0.22 vs. 0.31 +/- 0.26 nmol/l, P = 0.018) and tended to fall less from clinical onset to 24 months in the diazoxide- vs. placebo-treated patients (-0.05 +/- 0.24 vs. -0.18 +/- 0.26 nmol/l, P = 0.064). At 24 months, the meal-stimulated C-peptide concentrations were 0.24 +/- 0.20 and 0.20 +/- 0.17 nmol/l, respectively. Side effects of diazoxide were prevalent. CONCLUSIONS: This study demonstrates that partial inhibition of insulin secretion for 3 months at onset of childhood type 1 diabetes suspends the period of remission and temporarily preserves residual insulin production. Further evaluation of the full potential of beta-cell rest will require compounds with less side effects as well as protocols optimized for sustained secretory arrest.
Keyword
- Adolescent
- C-Peptide/blood
- Child
- Diabetes Mellitus
- Type 1/*drug therapy
- Diazoxide/*therapeutic use
- Female
- Humans
- Hypoglycemic Agents/therapeutic use
- Insulin/blood/secretion/therapeutic use
- Islets of Langerhans/drug effects/*secretion
- Male
- Vasodilator Agents/*therapeutic use
- Adolescent
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Ortqvist, E.
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Björk, Elisabeth
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Wallensteen, M.
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Ludvigsson, John ...
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Aman, J.
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Johansson, C.
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show more...
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Forsander, Gun, ...
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Lindgren, F.
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Berglund, Lars
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Bengtsson, Mats
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Berne, Christian
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Persson, B.
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Karlsson, F. A.
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show less...
- Articles in the publication
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Diabetes Care
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet
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Linköping University