id:"swepub:oai:gup.ub.gu.se/53283"
Search: id:"swepub:oai:gup.ub.gu.se/53283" > Bet v 1-specific Ig...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Keen, ChristinaGothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Göteborg, Sweden (author)
Bet v 1-specific IgA increases during the pollen season but not after a single allergen challenge in children with birch pollen-induced intermittent allergic rhinitis
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- Wiley-Blackwell,2005
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/53283
- https://gup.ub.gu.se/publication/53283URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-98558URI
- https://doi.org/10.1111/j.1399-3038.2005.00264.xDOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Allergen-specific immunoglobulins of the Immunoglobulin A (IgA) type have been found in the nasal fluid of patients with allergic rhinitis. IgA may play a protective role, but there are also data which show that allergen-specific IgA can induce eosinophil degranulation. The aim of this study was to quantitate Bet v 1-specific IgA in relation to total IgA in the nasal fluid of children with birch pollen-induced intermittent allergic rhinitis and healthy controls, after allergen challenge and during the natural pollen season. Eosinophil cationic protein (ECP), Bet v 1-specific IgA and total IgA were analyzed in nasal fluids from 30 children with birch pollen-induced intermittent allergic rhinitis and 30 healthy controls. Samples were taken before the pollen season, after challenge with birch pollen and during the pollen season, before and after treatment with nasal steroids. During the pollen season, but not after nasal allergen challenge, Bet v 1-specific IgA increased in relation to total IgA in children with allergic rhinitis. No change was found in the healthy controls. The ratio of Bet v 1-specific IgA to total IgA increased from 0.1 x 10(-3) (median) to 0.5 x 10(-3) in the allergic children, p < 0.001. No change was seen after treatment with nasal steroids, although symptoms, ECP and eosinophils were reduced. In conclusion, allergen-specific IgA in relation to total IgA increases in nasal fluids during the pollen season in allergic children but not in healthy controls. These findings are compatible with the hypothesis that allergen-specific IgA plays a role in the allergic inflammation and further studies are needed to clarify the functional role of these allergen-specific antibodies.
Subject headings and genre
- Adolescent
- Allergens/administration & dosage/adverse effects/*immunology
- Anti-Inflammatory Agents/therapeutic use
- *Antibody Specificity
- Betula/adverse effects/immunology
- Budesonide/therapeutic use
- Child
- Hay Fever/drug therapy/etiology/*immunology
- Humans
- Immunoglobulin A/*blood
- Nasal Lavage Fluid/immunology
- Nasal Mucosa/*immunology
- Nasal Provocation Tests
- Plant Proteins/*immunology
- Pollen/*adverse effects/immunology
- Research Support
- Non-U.S. Gov't
- Seasons
- allergen-specific IgA; allergic rhinitis; children; nasal secretions
Added entries (persons, corporate bodies, meetings, titles ...)
- Johansson, S.Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Göteborg, Sweden (author)
- Reinholdt, J.Department of Oral Biology, Royal Dental College, Aarhus, Denmark (author)
- Benson, Mikael,1954Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Göteborg, Sweden(Swepub:liu)mikbe05 (author)
- Wennergren, Göran,1947Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Göteborg, Sweden(Swepub:gu)xwengo (author)
- Göteborgs universitetInstitutionen för kvinnors och barns hälsa, Avdelningen för pediatrik (creator_code:org_t)
Related titles
- In:Pediatr Allergy Immunol: Wiley-Blackwell16:3, s. 209-160905-61571399-3038
Internet link
Find in a library
- Pediatr Allergy Immunol (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Keen, Christina
- Johansson, S.
- Reinholdt, J.
- Benson, Mikael, ...
- Wennergren, Göra ...
- Articles in the publication
- Pediatr Allergy ...
- By the university
- University of Gothenburg
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
