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Insulin-like growth...
Insulin-like growth factor-1, leptin, body composition, and clinical status interactions in children with cystic fibrosis
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Boguszewski, M. C. (författare)
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Kamoi, T. O. (författare)
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Bento Radominski, R. (författare)
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Boguszewski, C. L. (författare)
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- Rosberg, Sten, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Filho, N. A. (författare)
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Sandrini Neto, R. (författare)
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- Albertsson-Wikland, Kerstin, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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(creator_code:org_t)
- 2007-01-10
- 2007
- Engelska.
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Ingår i: Horm Res. - : S. Karger AG. - 0301-0163. ; 67:5, s. 250-6
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND/AIMS: Children with cystic fibrosis (CF) are of increased risk of reduced fat body mass (FBM) and lean body mass (LBM). Serum concentrations of insulin-like growth factor-1 (IGF-1)and leptin could be markers of LBM and/or FBM depletion. To evaluate the relationships between disease activity, body composition, IGF-1 and leptin concentrations in CF children. METHODS: A cross-sectional study with 26 CF children aged 5.0-15.5 years and 33 healthy controls, mean age 9.4 years. Body composition was evaluated by dual-energy X-ray absorptiometry. Fasting blood samples were analyzed for leptin, IGF-1 and IGFBP-3. RESULTS: FBM standard deviation score (SDS; CF boys -0.02 +/- 0.88 vs. 0.78 +/- 0.65, p < 0.01; CF girls -0.37 +/- 1.15 vs. 0.70 +/- 0.97, p < 0.05), leptin concentration (CF boys 2.07 +/- 0.79 vs. 3.07 +/- 1.28 ng/ml, p < 0.05; CF girls 2.71 +/- 0.86 vs. 5.00 +/- 2.95 ng/ml, p < 0.05) and IGF-1SDS (CF boys -1.43 +/- 1.50 vs. -0.32 +/- 0.88, p < 0.05; CF girls -0.66 +/- 1.66 vs. 0.64 +/- 0.57, p < 0.01) were lower in CF children compared to controls. Shwachman score was the strongest predictor of lean body mass (R = 0.63). Leptin levels explain 60% of the variability in FBM. CONCLUSION: Serum concentrations of IGF-1 and leptin are decreased in children with CF and are associated with clinical conditions and body composition.
Nyckelord
- Adipose Tissue/anatomy & histology
- Adolescent
- Biological Markers/blood
- *Body Composition
- Child
- Child Development
- Child
- Preschool
- Cross-Sectional Studies
- Cystic Fibrosis/*blood
- Female
- Humans
- Inflammation/blood
- Insulin-Like Growth Factor I/*analysis
- Leptin/*blood
- Male
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Horm Res
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