Antibodies against Haemophilus influenzae type b capsular polysaccharide and tetanus toxoid before and after a booster dose of the carrier protein nine years after primary vaccination with a protein conjugate vaccine.

• IgG antibodies against Haemophilus influenzae type b (Hib) capsular polysaccharide (CPS) and tetanus toxoid (TT) were measured for 53 children, 10 years of age, before and 1 month after a booster dose of diphtheria-tetanus vaccine (DT). All children had been vaccinated at 3, 5 and 12 months of age with DT and a Hib-TT conjugate. Geometric mean concentrations of Hib CPS serum IgG antibody were 4.16 and 4.30 microg/mL before and after the DT booster, respectively. The geometric mean concentration of TT IgG antibody increased from 0.09 IU/mL to 4.58 IU/mL (P < 0.001). Hib CPS IgG levels remained well above protective titers for 9 years after 3 doses of Hib-TT appropriately spaced in infancy. A booster dose of TT did not affect Hib CPS antibody concentrations but induced a pronounced IgG response against TT.

Keyword

Antibodies

Bacterial

analysis

immunology

Carrier Proteins

immunology

Child

Cohort Studies

Female

Follow-Up Studies

Haemophilus Infections

immunology

prevention & control

Haemophilus Vaccines

administration & dosage

immunology

Humans

Immunization Schedule

Immunization

Secondary

Male

Sensitivity and Specificity

Tetanus Toxoid

administration & dosage

immunology

Time Factors

Vaccination

Vaccines

Conjugate

analysis

immunology

Publication and Content Type

ref (subject category)

for (subject category)