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Off-pump CABG reduc...
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Johansson-Synnergren, Mats,1968
(författare)
Off-pump CABG reduces complement activation but does not significantly affect peripheral endothelial function: a prospective randomized study.
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
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2009-07-12
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Informa UK Limited,2004
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/53514
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https://gup.ub.gu.se/publication/53514URI
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https://doi.org/10.1080/14017430410024847DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVE--Cardiac surgery initiates a systemic inflammatory response, which may affect endothelial function. The aim of this study was to investigate if off-pump CABG (OPCAB) reduces the postoperative inflammatory response and affects endothelial function less than conventional on-pump CABG. DESIGN--Fifty-two patients submitted for elective CABG were included in a prospective, randomized study. Twenty-six patients were operated with, and 26 without cardiopulmonary bypass (CPB). Plasma levels of complement (C3a), cytokines (IL-8, TNF-alpha), endothelin-1 and neopterin were measured before and during surgery and 2 and 24 h after surgery. Endothelial function was assessed by forearm plethysmography and acetylcholine infusion in 30 patients 2-4 h after surgery. RESULTS--C3a and neopterin concentrations were significantly higher during and early after surgery in the CPB group while TNF-alpha and IL-8 tended to be higher in the CPB group but the difference did not reach statistical significance. Endothelial function did not differ significantly between the two groups. CONCLUSION--OPCAB reduces complement activation compared with on-pump CABG but does not significantly affect TNF-alpha and IL-8 release or endothelial function.
Ämnesord och genrebeteckningar
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Acetylcholine
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administration & dosage
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Area Under Curve
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Biological Markers
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blood
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Cardiopulmonary Bypass
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Complement Activation
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drug effects
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physiology
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Complement C3a
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drug effects
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metabolism
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Coronary Artery Bypass
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Dose-Response Relationship
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Drug
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Endothelin-1
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blood
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drug effects
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Endothelium
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Vascular
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metabolism
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physiopathology
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surgery
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Female
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Forearm
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blood supply
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Humans
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Interleukin-8
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blood
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Male
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Middle Aged
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Neopterin
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blood
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Nitroprusside
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administration & dosage
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Prospective Studies
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Regional Blood Flow
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drug effects
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physiology
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Treatment Outcome
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Tumor Necrosis Factor-alpha
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drug effects
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metabolism
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Vasodilation
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drug effects
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physiology
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Vasodilator Agents
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administration & dosage
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nilsson, Folke,1950Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xnilfo
(författare)
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Bengtsson, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care(Swepub:gu)xbeand
(författare)
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Jeppsson, Anders,1960Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xjepan
(författare)
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Wiklund, Lars,1954Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xwikla
(författare)
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Göteborgs universitetHjärt-kärlinstitutionen
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scandinavian cardiovascular journal : SCJ: Informa UK Limited38:1, s. 53-81401-74311651-2006
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