WFRF:(Hultgren Hörnquist Elisabeth)
Sökning: WFRF:(Hultgren Hörnquist Elisabeth) > Enhanced pro-inflam...
Enhanced pro-inflammatory cytokine production in Galphai2-deficient mice on colitis prone and colitis resistant 129Sv genetic backgrounds.
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- Bjursten, Malin, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology
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- Hultgren, Olof H., 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology
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- Hultgren-Hörnquist, Elisabeth, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology
- (creator_code:org_t)
- Elsevier BV, 2004
- 2004
- Engelska.
- Ingår i: Cellular immunology. - : Elsevier BV. - 0008-8749. ; 228:2, s. 77-80
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Mice deficient in G-protein subunit alphai2 develop colitis closely resembling human ulcerative colitis when raised on 129SvEv background. When backcrossing the Galphai2-deficiency into a 129SvJBom genetic background, surprisingly, mice did not develop colitis. In vitro stimulation of splenocytes with formalin-killed Staphylococcus aureus resulted in significantly increased production of interleukin-1beta, tumor necrosis factor, and interleukin-12p40 in Galphai2(-/-) as compared to control mice. The enhanced production of pro-inflammatory cytokines was seen in colitis prone as well as in colitis resistant genetic background. A similar outcome was seen upon stimulation with toxic shock syndrome toxin-1, a T cell superantigen, except that Galphai2(-/-) colitis resistant 129SvJBom splenocytes did not show increased production of IL-12p40 as compared to their controls.
Nyckelord
- Animals
- Bacterial Toxins
- immunology
- Colitis
- genetics
- immunology
- metabolism
- Cytokines
- biosynthesis
- immunology
- Enterotoxins
- immunology
- Female
- GTP-Binding Protein alpha Subunits
- Gi-Go
- deficiency
- immunology
- Interleukin-1
- biosynthesis
- immunology
- Interleukin-10
- biosynthesis
- immunology
- Interleukin-12
- biosynthesis
- immunology
- Interleukin-12 Subunit p40
- Male
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Minor Lymphocyte Stimulatory Antigens
- immunology
- Protein Subunits
- biosynthesis
- immunology
- Staphylococcus aureus
- immunology
- Statistics
- Nonparametric
- Superantigens
- immunology
- Tumor Necrosis Factor-alpha
- biosynthesis
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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