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Enhanced pro-inflam...
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Bjursten, Malin,1976Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology
(författare)
Enhanced pro-inflammatory cytokine production in Galphai2-deficient mice on colitis prone and colitis resistant 129Sv genetic backgrounds.
- Artikel/kapitelEngelska2004
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Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/53915
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https://gup.ub.gu.se/publication/53915URI
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https://doi.org/10.1016/j.cellimm.2004.05.001DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Mice deficient in G-protein subunit alphai2 develop colitis closely resembling human ulcerative colitis when raised on 129SvEv background. When backcrossing the Galphai2-deficiency into a 129SvJBom genetic background, surprisingly, mice did not develop colitis. In vitro stimulation of splenocytes with formalin-killed Staphylococcus aureus resulted in significantly increased production of interleukin-1beta, tumor necrosis factor, and interleukin-12p40 in Galphai2(-/-) as compared to control mice. The enhanced production of pro-inflammatory cytokines was seen in colitis prone as well as in colitis resistant genetic background. A similar outcome was seen upon stimulation with toxic shock syndrome toxin-1, a T cell superantigen, except that Galphai2(-/-) colitis resistant 129SvJBom splenocytes did not show increased production of IL-12p40 as compared to their controls.
Ämnesord och genrebeteckningar
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Animals
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Bacterial Toxins
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immunology
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Colitis
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genetics
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immunology
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metabolism
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Cytokines
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biosynthesis
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immunology
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Enterotoxins
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immunology
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Female
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GTP-Binding Protein alpha Subunits
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Gi-Go
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deficiency
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immunology
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Interleukin-1
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biosynthesis
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immunology
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Interleukin-10
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biosynthesis
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immunology
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Interleukin-12
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biosynthesis
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immunology
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Interleukin-12 Subunit p40
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Male
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Mice
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Mice
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Inbred C57BL
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Mice
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Knockout
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Minor Lymphocyte Stimulatory Antigens
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immunology
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Protein Subunits
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biosynthesis
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immunology
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Staphylococcus aureus
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immunology
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Statistics
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Nonparametric
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Superantigens
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immunology
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Tumor Necrosis Factor-alpha
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biosynthesis
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immunology
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hultgren, Olof H.,1970Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology(Swepub:gu)xhulol
(författare)
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Hultgren-Hörnquist, Elisabeth,1965Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology(Swepub:gu)xhorel
(författare)
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Göteborgs universitetInstitutionen för laboratoriemedicin, Avdelningen för klinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cellular immunology: Elsevier BV228:2, s. 77-800008-8749
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