Sökning: WFRF:(Dahlén Kristian 1973) >
Synthesis of 3-amin...
Synthesis of 3-aminomethyl-2-aryl- 8-bromo-6-chlorochromones.
-
- Wallén, Erik A A (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
-
- Dahlén, Kristian, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
-
- Grøtli, Morten, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
-
visa fler...
-
- Luthman, Kristina, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
-
visa färre...
-
(creator_code:org_t)
- 2007-01-05
- 2007
- Engelska.
-
Ingår i: Organic letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 9:3, s. 389-91
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- [reaction: see text] An efficient synthetic route to Cbz-protected 3-aminomethyl-2-aryl-8-bromo-6-chlorochromones has been developed. 3-Aryl-1-(3-bromo-5-chloro-2-hydroxyphenyl)-2-propen-1-one or 2-aryl-8-bromo-6-chlorochroman-4-one could be reacted under Mannich conditions yielding 2-aryl-8-bromo-6-chloro-3-methylenechroman-4-one, which was further converted to the target compound via an aza-Michael reaction followed by an SeO(2) oxidation. This procedure represents a new method to introduce a primary aminomethyl group at the 3-position of a 2-arylchromone scaffold. The Cbz-protected 3-aminomethyl-2-aryl-8-bromo-6-chlorochromones can, e.g., be used in the synthesis of chromone-based beta-turn peptidomimetics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- Amines
- chemistry
- Biomimetic Materials
- chemistry
- Chromones
- chemistry
- Flavonoids
- chemical synthesis
- Models
- Chemical
- Oxidation-Reduction
- Peptides
- chemistry
- Selenium Compounds
- chemistry
- Stereoisomerism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas