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Postnatal lymphatic...
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Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor
- Article/chapterEnglish2007
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LIBRIS-ID:oai:gup.ub.gu.se/54423
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https://gup.ub.gu.se/publication/54423URI
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Lymphatic vessels develop from specialized venous endothelial cells. Using knockout mice, we found that fasting-induced adipose factor (Fiaf) is required for functional partitioning of postnatal intestinal lymphatic and blood vessels. In wild-type animals, levels of intestinal Fiaf expression rise during the first postnatal day and peak at day 2, which coincides with the onset of the lymphatico-venous partitioning abnormality in Fiaf-/- mutants on a mixed 129/SvJ:C57BL/6 genetic background. Fiaf deficiency is not associated with disruption of the blood vasculature or with lymphatic endothelial recruitment of smooth muscle cells. We identified Prox1, a critical regulator of lymphangiogenesis, as a downstream target for Fiaf signaling in the intestinal lymphatic endothelium. This organ-specific lymphovascular abnormality can be rescued by allowing embryonic Fiaf-/- intestinal isografts to develop in Fiaf+/+ recipients.
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Crawford, P. A.
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O'Donnell, D.
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Gordon, J. I.
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
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In:Proc Natl Acad Sci U S A104:2, s. 606-611
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