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The fragrance chemi...
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Sköld, Maria,1976Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
(author)
The fragrance chemical beta-caryophyllene-air oxidation and skin sensitization.
- Article/chapterEnglish2006
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LIBRIS-ID:oai:gup.ub.gu.se/54597
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https://gup.ub.gu.se/publication/54597URI
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https://doi.org/10.1016/j.fct.2005.08.028DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Fragrances are common causes of allergic contact dermatitis. beta-Caryophyllene is a sesquiterpene that is used as a fragrance chemical. Analogous to the monoterpenes R-limonene and linalool, it can be expected to autoxidize when air exposed. The aim of the present study was to investigate the autoxidation of beta-caryophyllene and to evaluate the effect on the contact allergenic activity. beta-Caryophyllene started to oxidize immediately when air exposed and after 5 weeks almost 50% of the original compound was consumed. Caryophyllene oxide was found to be the major oxidation product. Hydroperoxides of beta-caryophyllene could not be detected in the oxidation mixture. Caryophyllene oxide was shown to be an allergen of moderate strength and beta-caryophyllene air exposed for 10 weeks showed a weak sensitizing capacity in the local lymph node assay. The study reveals that the allergenic activity of beta-caryophyllene is affected by autoxidation, but to a lesser extent when compared to R-limonene and linalool. The present findings support our results in clinical studies showing oxidized beta-caryophyllene to be a rather rare sensitizer compared to oxidized R-limonene and linalool.
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Karlberg, Ann-Therese,1947Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry(Swepub:gu)xkaann
(author)
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Matura, Mihaly,1964Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry(Swepub:gu)xmatmi
(author)
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Börje, Anna,1961Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry(Swepub:gu)xboann
(author)
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Göteborgs universitetInstitutionen för kemi
(creator_code:org_t)
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In:Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association: Elsevier BV44:4, s. 538-450278-6915
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