The impact of nicotine on osseointegration. An experimental study in the femur and tibia of rabbits.

OBJECTIVES: The aim of the present study was to analyze the effect of an enhanced systematic dose of nicotine on osseointegration of titanium implants. MATERIAL AND METHODS: Sixteen female rabbits received either nicotine (n=8) or saline (n=8) administered subcutaneously via mini-osmotic pumps for 2 months. The pump delivered 6 mug/kg/min of nicotine for the animals in the test group. Blood was withdrawn and plasma cotinine levels were measured weekly. Thirty-two titanium implants were inserted into the femur and tibia of all rabbits after 4 weeks and after 6 weeks of nicotine/placebo exposure. Thus, 2- and 4-week healing groups were created. Biomechanical evaluation by (i) resonance frequency analysis test (RFA) on all implants after insertion and before sacrifice and (ii) removal torque test (RMT) on tibial implants before sacrifice was performed. All implants placed in the femur were processed to undecalcified ground sections. The percentage of bone-to-implant contact (BIC) and of bone area within the threads (BD-i) were measured. RESULTS: No significant difference in RMT and RFA values was found between the test and the control group. Histomorphometric measurements of the BIC and the peri-implant BD-i showed no significant differences between the test and the control group after 2 or after 4 weeks. CONCLUSION: Nicotine exposure for a short period of time even in a high dose did not have a significant impact on implant osseointegration in rabbits.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
Animals
Biomechanics
Cotinine
blood
Dental Implants
Female
Femur
drug effects
pathology
Fluorescent Dyes
diagnostic use
Ganglionic Stimulants
administration & dosage
pharmacology
Infusion Pumps
Injections
Subcutaneous
Nicotine
administration & dosage
pharmacology
Osseointegration
drug effects
Placebos
Rabbits
Stress
Mechanical
Surface Properties
Tibia
drug effects
pathology
Titanium
chemistry
Torque
Vibration
test
removal torque
nicotine
implants
bone healing
histomorphometry
resonance frequency analysis
smoking

Gotfredsen, Klaus (författare)
Lindh, ChristianLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-cli (författare)
Berglundh, Tord,1954Gothenburg University,Göteborgs universitet,Odontologiska institutionen, Avdelningen för parodontologi,Institute of Odontology, Department of Periodontology(Swepub:gu)xbetor (författare)
Avdelningen för arbets- och miljömedicinInstitutionen för laboratoriemedicin (creator_code:org_t)

Av författaren/redakt...: Balatsouka, Dimi ...; Gotfredsen, Klau ...; Lindh, Christian; Berglundh, Tord, ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Odontologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Arbetsmedicin oc ...

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