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Matrix metalloprote...
Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression.
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Rauvala, M (författare)
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- Aglund, Kristina (författare)
- Umeå universitet,Onkologi
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Puistola, U (författare)
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Turpeenniemi-Hujanen, T (författare)
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- Horvath, György, 1942 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Willén, R (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Stendahl, U (författare)
- Umeå universitet,Onkologi
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(creator_code:org_t)
- BMJ, 2006
- 2006
- Engelska.
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Ingår i: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. - : BMJ. - 1048-891X .- 1525-1438. ; 16:3, s. 1297-302
- Relaterad länk:
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http://www.ncbi.nlm....
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The incidence of uterine cervical cancer has increased slightly in Western countries, with an increase in relatively young women. Overexpression of matrix metalloproteinases (MMPs)-2 and -9 has turned out as a prognostic factor in many cancers. We compared the expression of the proteins MMP-2 and MMP-9 in cervical primary tumors with clinical outcome and risk factors of cervical cancer. One hundred sixty-one patients with cervical cancer treated in Umeå University Hospital or Sahlgrenska University Hospital, Sweden, between 1991 and 1995 were included in the study. Paraffin-embedded tissue samples obtained prior to treatment were examined immunohistochemically by specific antibodies for MMP-2 and MMP-9. Forty-two percent of the tumors were intensively positive for MMP-2 and 31% for MMP-9. Nineteen percent of the samples were intensively positive for both proteinases and 47% negative or weak for both. Overexpression of MMP-2 seemed to predict unfavorable survival under Kaplan-Meier analysis and in the multivariate analysis. Early sexual activity and low parity seemed to correlate to overexpression of MMP-2. MMP-9 was not associated with survival or sexual behavior. Intensive MMP-9 was noted in grade 1 tumors. We conclude that MMP-2 and MMP-9 have different roles in uterine cervical cancer. MMP-2 could be associated with aggressive behavior, but MMP-9 expression diminishes in high-grade tumors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adult
- Aged
- Aged
- 80 and over
- Carcinoma
- enzymology
- pathology
- Contraceptive Agents
- Female
- pharmacology
- Disease Progression
- Female
- Humans
- Matrix Metalloproteinase 2
- physiology
- Matrix Metalloproteinase 9
- physiology
- Middle Aged
- Parity
- Pregnancy
- Retrospective Studies
- Sexual Behavior
- statistics & numerical data
- Survival Rate
- Uterine Cervical Neoplasms
- enzymology
- pathology
- cervical cancer
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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