Inhibition of the sensitizing effect of carvone by the addition of non-allergenic compounds.

Nilsson, Anna-Malin,1972Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry (author)

We have previously reported a reduction of sensitization to carvone in guinea pigs when adding non-allergenic, structurally related compounds simultaneously at induction. This study investigates the criteria needed to obtain a reduction of sensitization in contact allergy. Linalool, a non-sensitizer structurally unrelated to carvone, significantly reduced the sensitizing capacity of carvone in guinea pigs. The effect of different concentrations of inhibitors in mixtures with carvone was investigated. No significant differences in response were obtained between the concentrations explored. A possible anti-inflammatory effect from the inhibitory chemicals was investigated in vitro. No suppression of the immune system was seen. This study shows that a non-allergenic compound with a structure not resembling the hapten can reduce the sensitizing effect of the hapten. It indicates that reduction of an allergenic effect might occur in consumer products that are mixtures of different chemicals. Further studies with chemically unrelated compounds with and without allergenic effect are needed.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Läkemedelskemi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medicinal Chemistry hsv//eng
Allergens
adverse effects
Analysis of Variance
Animals
Cross Reactions
Cytokines
metabolism
Dermatitis
Allergic Contact
etiology
immunology
Disease Models
Animal
Female
Guinea Pigs
Immunization
methods
Lymphocyte Activation
Monoterpenes
pharmacology
Patch Tests
Probability
Sensitivity and Specificity
Terpenes
pharmacology

Jonsson, Charlotte A,1971Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry(Swepub:gu)xjonch (author)
Luthman, Kristina,1953Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry(Swepub:gu)xlutkr (author)
Nilsson, J Lars GGothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry (author)
Karlberg, Ann-Therese,1947Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry(Swepub:gu)xkaann (author)
Göteborgs universitetInstitutionen för kemi (creator_code:org_t)

In:Acta dermato-venereologica: Medical Journals Sweden AB84:2, s. 99-1050001-5555

By the author/editor: Nilsson, Anna-Ma ...; Jonsson, Charlot ...; Luthman, Kristin ...; Nilsson, J Lars ...; Karlberg, Ann-Th ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medicinal Chemis ...

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