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IP-10 predicts vira...
IP-10 predicts viral response and therapeutic outcome in difficult-to-treat patients with HCV genotype 1 infection
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- Lagging, Martin, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Romero, Ana, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Westin, Johan, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Norkrans, Gunnar, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Dhillon, Amar P (author)
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Pawlotsky, Jean-Michel (author)
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Zeuzem, Stefan (author)
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von Wagner, Michael (author)
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Negro, Francesco (author)
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Schalm, Solko W (author)
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Haagmans, Bart L (author)
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Ferrari, Carlo (author)
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Missale, Gabriele (author)
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Neumann, Avidan U (author)
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Verheij-Hart, Elke (author)
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- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Hepatology. - : Ovid Technologies (Wolters Kluwer Health). - 0270-9139 .- 1527-3350. ; 44:6, s. 1617-25
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Plasma from 173 patients with HCV genotype 1 infection was analyzed for IP-10 levels prior to treatment with pegylated interferon-alpha-2a and ribavirin. Significantly lower IP-10 levels were observed in patients achieving a rapid viral response (RVR) (P < .0001), even in those with body mass index (BMI) > or = 25 kg/m2 (P = .004) and with baseline viral load > or = 2 million IU/mL (P = .001). Similarly, significantly lower IP-10 levels were observed in patients obtaining a sustained viral response (SVR) (P = .0002), including those having higher BMI (P < .05), higher viral load (P = .0005), and both higher BMI and viral load (P < .03). In multivariate logistic regression analyses, a low IP-10 value was independently predictive of both RVR and SVR. A baseline cutoff IP-10 value of 600 pg/mL yielded a negative predictive value (NPV) of 79% (19/24) for all genotype 1-infected patients, which was comparable with that observed using a reduction in HCV-RNA by at least 2 logs after 12 weeks of therapy (NPV 86%; 19/22); by combining the two, 30 of 38 patients (NPV 79%) potentially could have been spared unnecessary therapy. In patients having both higher BMI and viral load, cut-off levels of 150 and 600 pg/mL yielded a positive predictive value (PPV) of 71% and NPV of 100%, respectively. In conclusion, pretreatment IP-10 levels predict RVR and SVR in patients infected with HCV genotype 1, even in those with higher BMI and viral load. A substantial proportion of the latter patients may achieve SVR in spite of unfavorable baseline characteristics if their pretreatment IP-10 level is low. Thus, pretreatment IP-10 analysis may prove helpful in decision-making regarding pharmaceutical intervention.
Keyword
- Adult
- Body Mass Index
- Chemokines
- CXC/ blood
- Female
- Hepacivirus/ genetics
- Hepatitis C
- Chronic/ drug therapy/virology
- Humans
- Interferon Alfa-2a/therapeutic use
- Logistic Models
- Male
- Middle Aged
- Polyethylene Glycols/therapeutic use
- Predictive Value of Tests
- RNA
- Viral/analysis
- Ribavirin/therapeutic use
- Sensitivity and Specificity
- Treatment Outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hepatology
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- By the author/editor
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Lagging, Martin, ...
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Romero, Ana, 197 ...
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Westin, Johan, 1 ...
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Norkrans, Gunnar ...
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Dhillon, Amar P
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Pawlotsky, Jean- ...
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show more...
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Zeuzem, Stefan
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von Wagner, Mich ...
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Negro, Francesco
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Schalm, Solko W
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Haagmans, Bart L
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Ferrari, Carlo
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Missale, Gabriel ...
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Neumann, Avidan ...
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Verheij-Hart, El ...
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Hellstrand, Kris ...
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- Articles in the publication
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Hepatology
- By the university
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University of Gothenburg