Increased myocardial repolarization lability and reduced cardiac baroreflex sensitivity in individuals with high-normal blood pressure

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Myredal Anna 1975) > Increased myocardia...

Myredal, Anna,1975Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute (författare)

Increased myocardial repolarization lability and reduced cardiac baroreflex sensitivity in individuals with high-normal blood pressure

Artikel/kapitelEngelska2005

Förlag, utgivningsår, omfång ...

2005

Nummerbeteckningar

LIBRIS-ID:oai:gup.ub.gu.se/55200
https://gup.ub.gu.se/publication/55200URI

Kompletterande språkuppgifter

Språk:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

BACKGROUND: Recent guidelines for the management of arterial hypertension have proposed that, to prevent cardiovascular disease, lifestyle modifications are required even in the case of high-normal blood pressure (HNBP). OBJECTIVE: To assess myocardial repolarization and spontaneous cardiac baroreflex sensitivity (BRS) in newly diagnosed and never-treated individuals. DESIGN AND PARTICIPANTS: We studied healthy individuals with HNBP according to the 2003 European Society of Hypertension-ESC guidelines and, for comparison, patients with renovascular hypertension (RVH) and healthy individuals with normal blood pressure (NBP). MAIN OUTCOME MEASURES: Electrocardiogram and beat-to-beat blood pressure were recorded and spontaneous cardiac baroreflex sensitivity and the temporal QT interval variability index (QTVI) were calculated. RESULTS: Individuals with HNBP had increased QTVI values compared with those with NBP (-1.23 +/- 0.37 compared with -1.52 +/- 0.26; P < 0.05), whereas patients with RVH had additionally increased QTVI values that were greater than those in healthy individuals with NBP or HNBP (-0.81 +/- 0.75; P < 0.05 compared with both groups). BRS was reduced in both groups of individuals with increased blood pressures compared with NBP (8.2 +/- 4.1 ms/mmHg for individuals with HNBP, 6.1 +/- 4.3 ms/mmHg for patients with RVH and 10.8 +/- 3.5 ms/mmHg for NBP; P < 0.05 for both). CONCLUSION: In otherwise healthy individuals, even a moderate blood pressure increase is associated with increased myocardial repolarization lability and reduced baroreflex sensitivity (BRS). Patients with RVH have an additionally increased QTVI, with values similar to those reported in congestive heart failure. Future studies are needed to establish the value of QTVI and BRS measurements among individuals with HNBP in predicting the risk of progression to hypertension and end-organ damage.

Ämnesord och genrebeteckningar

Aged
Autonomic Nervous System/*physiopathology
Baroreflex/*physiology
Blood Pressure
Case-Control Studies
Electrocardiography
Female
Heart Rate
Humans
*Hypertension
Hypertension
Renal/physiopathology
Long QT Syndrome/physiopathology
Male
Middle Aged
Renal Artery Obstruction/complications/physiopathology
Sensitivity and Specificity

Biuppslag (personer, institutioner, konferenser, titlar ...)

Gao, Sinsia,1966Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xgaosi (författare)
Friberg, Peter,1956Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xfrpet (författare)
Jensen, Gert,1950Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xjenge (författare)
Larsson, Lars (författare)
Johansson, Mats,1959Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute (författare)
Göteborgs universitetHjärt-kärlinstitutionen (creator_code:org_t)

Sammanhörande titlar

Ingår i:J Hypertens23:9, s. 1751-60263-6352

Internetlänk

https://gup.ub.gu.se/publication/55200

Hitta via bibliotek

J Hypertens (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Myredal, Anna, 1 ...; Gao, Sinsia, 196 ...; Friberg, Peter, ...; Jensen, Gert, 19 ...; Larsson, Lars; Johansson, Mats, ...

Artiklar i publikationen: J Hypertens

Av lärosätet: Göteborgs universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se