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Decreased renal sym...
Decreased renal sympathetic activity in response to cardiac unloading with nitroglycerin in patients with heart failure
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- Petersson, Magnus, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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- Friberg, Peter, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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Lambert, G. (författare)
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visa fler...
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- Rundqvist, Bengt, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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visa färre...
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Eur J Heart Fail. - 1388-9842. ; 7:6, s. 1003-10
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- AIMS: To examine changes in renal sympathetic outflow in response to cardiac unloading with nitroglycerin (GTN) in patients with chronic heart failure (CHF) and healthy subjects (HS). METHODS AND RESULTS: Renal (RNAsp) and total body (TBNAsp) noradrenaline (NA) spillover were measured with radiotracer methods in 16 patients with CHF (50+/-3 years, LVEF 20+/-1%) and nine HS (57+/-2 years) during right heart and renal vein catheterisation. Low dose GTN decreased mean pulmonary artery pressure (PAm: CHF -7+/-2 mm Hg, HS -4+/-1 mm Hg, p<0.05 vs. baseline) but not mean arterial pressure (MAP: CHF -2+/-1 mm Hg, HS -2+/-1 mm Hg) and did not affect RNAsp in any of the study groups. High dose GTN lowered MAP (CHF -12+/-1 mm Hg, HS -12+/-2 mm Hg, p<0.05 vs. baseline) and PAm (CHF -13+/-2 mm Hg, HS -5+/-1 mm Hg, p<0.05 vs. baseline) and was accompanied by a significant reduction in RNAsp only in CHF (1.3+/-0.1 nmol/min baseline to 0.9+/-0.2 nmol/min, p<0.05), whereas RNAsp in HS remained unchanged. CONCLUSIONS: In spite of a reduction in both arterial pressure and cardiac filling pressures, renal sympathetic activity decreased in CHF and did not increase in HS. These findings suggest that the altered loading conditions resulting from high-dose GTN infusion have renal sympathoinhibitory effects.
Nyckelord
- Analysis of Variance
- Case-Control Studies
- Dose-Response Relationship
- Drug
- Female
- Follow-Up Studies
- Heart Catheterization
- Heart Failure
- Congestive/*diagnosis/*drug therapy
- Hemodynamic Processes/physiology
- Humans
- Infusions
- Intravenous
- Kidney/drug effects/*radionuclide imaging
- Kidney Function Tests
- Male
- Middle Aged
- Nitroglycerin/*pharmacokinetics/therapeutic use
- Probability
- Reference Values
- Renal Circulation/drug effects/physiology
- Risk Assessment
- Severity of Illness Index
- Statistics
- Nonparametric
- Sympathetic Nervous System/*drug effects
- Ventricular Dysfunction
- Left/diagnosis/drug therapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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