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- Bella, J. N. (författare)
Sex-related difference in regression of left ventricular hypertrophy with antihypertensive treatment: the LIFE study
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
- 2004
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/56086
- https://gup.ub.gu.se/publication/56086URI
Kompletterande språkuppgifter
- Språk:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- While left ventricular (LV) structure and function differ between hypertensive women and men, it remains unclear whether sex affects regression of LV hypertrophy with antihypertensive treatment. We analysed paired echocardiograms in 500 men and 347 women enrolled in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study at baseline and after 12 months of antihypertensive treatment with either losartan or atenolol. At enrollment, 177 women and 242 men were randomized to losartan-based treatment and 161 women and 247 men were randomized to atenolol-based treatment (sex difference=NS). After 12 months of antihypertensive treatment, blood pressure was lowered similarly in women (152/83 from 174/97 mmHg) and men (149/85 from 173/99 mmHg; both P<0.001, sex difference=NS), without significant change in body weight in either sex. Cardiac output and pulse pressure/stroke volume were equivalently reduced in both sexes (-0.2 vs -0.1 l/min and both -0.20 mmHg/ml/m(2), respectively; both P=NS). Absolute LV mass change after 12 months of antihypertensive treatment was greater in men than in women (-30 vs -24 g, P=0.01). However, after adjusting for baseline LV mass and randomized study treatment, LV mass reduction was greater in women than in men (-33 vs -23 g, P=0.001). LV mass regression was greater in women, by 8.0+/-2.8 g, after adjusting for baseline LV mass and randomized study treatment. After consideration of baseline LV mass and randomized study treatment, antihypertensive treatment regressed LV hypertrophy more in women. Further studies are needed to identify the mechanisms and prognostic implications of this sex-related difference.
Ämnesord och genrebeteckningar
- Aged
- Aged
- 80 and over
- Antihypertensive Agents/*therapeutic use
- Atenolol/*therapeutic use
- Female
- Follow-Up Studies
- Heart Ventricles/ultrasonography
- Humans
- Hypertension/drug therapy
- Hypertrophy
- Left Ventricular/drug therapy/*ultrasonography
- Losartan/*therapeutic use
- Male
- Middle Aged
- Remission Induction
- *Sex Factors
- Time Factors
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Palmieri, V. (författare)
- Wachtell, K. (författare)
- Liu, J. E. (författare)
- Gerdts, E. (författare)
- Nieminen, M. S. (författare)
- Koren, M. J. (författare)
- Zabalgoitia, M. (författare)
- Wright, J. T. (författare)
- Dahlöf, Björn,1953Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xdahbj (författare)
- Devereux, R. B. (författare)
- Göteborgs universitetHjärt-kärlinstitutionen (creator_code:org_t)
Sammanhörande titlar
- Ingår i:J Hum Hypertens18:6, s. 411-60950-9240
Internetlänk
Hitta mer i SwePub
- Av författaren/redakt...
- Bella, J. N.
- Palmieri, V.
- Wachtell, K.
- Liu, J. E.
- Gerdts, E.
- Nieminen, M. S.
- visa fler...
- Koren, M. J.
- Zabalgoitia, M.
- Wright, J. T.
- Dahlöf, Björn, 1 ...
- Devereux, R. B.
- visa färre...
- Artiklar i publikationen
- J Hum Hypertens
- Av lärosätet
- Göteborgs universitet
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