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Sökning: onr:"swepub:oai:gup.ub.gu.se/56090" > Cardiovascular risk...

  • Julius, S. (författare)

Cardiovascular risk reduction in hypertensive black patients with left ventricular hypertrophy: the LIFE study

  • Artikel/kapitelEngelska2004

Förlag, utgivningsår, omfång ...

  • 2004

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/56090
  • https://gup.ub.gu.se/publication/56090URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • OBJECTIVES: We report on a subanalysis of the effects of losartan and atenolol on cardiovascular events in black patients in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. BACKGROUND: The LIFE study compared losartan-based to atenolol-based therapy in 9,193 hypertensive patients with left ventricular hypertrophy (LVH). Overall, the risk of the primary composite end point (cardiovascular death, stroke, myocardial infarction) was reduced by 13% (p = 0.021) with losartan, with similar blood pressure (BP) reduction in both treatment groups. There was a suggestion of interaction between ethnic background and treatment (p = 0.057). METHODS: Exploratory analyses were performed that placed LIFE study patients into black (n = 533) and non-black (n = 8,660) categories, overall, and in the U.S. (African American [n = 523]; non-black [n = 1,184]). RESULTS: A significant interaction existed between the dichotomized groups (black/non-black) and treatment (p = 0.005); a test for qualitative interaction was also significant (p = 0.016). The hazard ratio (losartan relative to atenolol) for the primary end point favored atenolol in black patients (1.666 [95% confidence interval (CI) 1.043 to 2.661]; p = 0.033) and favored losartan in non-blacks (0.829 [95% CI 0.733 to 0.938]; p = 0.003). In black patients, BP reduction was similar in both groups, and regression of electrocardiographic-LVH was greater with losartan. CONCLUSIONS: Results of the subanalysis are sufficient to generate the hypothesis that black patients with hypertension and LVH might not respond as favorably to losartan-based treatment as non-black patients with respect to cardiovascular outcomes, and do not support a recommendation for losartan as a first-line treatment for this purpose. The subanalysis is limited by the relatively small number of events.

Ämnesord och genrebeteckningar

  • African Continental Ancestry Group
  • Aged
  • Aged
  • 80 and over
  • Antihypertensive Agents/administration & dosage/*therapeutic use
  • Asian Continental Ancestry Group
  • Atenolol/administration & dosage/*therapeutic use
  • Blood Pressure/drug effects
  • Drug Therapy
  • Combination
  • Europe
  • European Continental Ancestry Group
  • Female
  • Humans
  • Hypertension/complications/genetics/mortality/*prevention & control
  • Hypertrophy
  • Left Ventricular/*complications
  • Losartan/administration & dosage/*therapeutic use
  • Male
  • Middle Aged
  • Treatment Outcome
  • United States

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Alderman, M. H. (författare)
  • Beevers, G. (författare)
  • Dahlöf, Björn,1953Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xdahbj (författare)
  • Devereux, R. B. (författare)
  • Douglas, J. G. (författare)
  • Edelman, J. M. (författare)
  • Harris, K. E. (författare)
  • Kjeldsen, S. E. (författare)
  • Nesbitt, S. (författare)
  • Randall, O. S. (författare)
  • Wright, J. T., Jr. (författare)
  • Göteborgs universitetHjärt-kärlinstitutionen (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:J Am Coll Cardiol43:6, s. 1047-550735-1097

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