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Type-specific react...
Type-specific reactivity of anti-glycoprotein G antibodies from herpes simplex virus-infected individuals is maintained by single or dual type-specific residues.
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- Tunbäck, Petra, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Laboratory Medicine, Dept of Clinical Virology,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology
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- Bergström, Tomas, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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- Löwhagen, Gun-Britt, 1942 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology
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Hoebeke, Johan (författare)
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- Liljeqvist, Jan-Åke, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology
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(creator_code:org_t)
- Microbiology Society, 2005
- 2005
- Engelska.
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Ingår i: The Journal of general virology. - : Microbiology Society. - 0022-1317 .- 1465-2099. ; 86:Pt 2, s. 247-51
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Glycoprotein G-1 (gG-1) of herpes simplex virus type 1 (HSV-1) and gG-2 of HSV-2 are the only known HSV proteins that induce type-specific human antibody responses. Recently, it was shown that purified human anti-gG-1 and anti-gG-2 antibodies presented a type-specific reactivity to immunogenic stretches with high similarity between gG-1 and gG-2. In this study, the molecular basis for this type-specific recognition was investigated employing synthetic peptides covering the indicated regions, including substitutions of the type-specific residues. The results revealed that single or dual type-specific residues localized within regions of high similarity could induce significant structural differences, explaining the type-specific recognition of the human antibody response to the gG proteins.
Nyckelord
- Amino Acid Substitution
- Antibodies
- Viral
- chemistry
- immunology
- Antibody Specificity
- Herpes Simplex
- blood
- immunology
- Herpesvirus 1
- Human
- immunology
- Herpesvirus 2
- Human
- immunology
- Humans
- Models
- Molecular
- Molecular Sequence Data
- Peptides
- chemical synthesis
- immunology
- Viral Envelope Proteins
- chemistry
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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