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Early acquisition o...
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Tunbäck, Petra,1965Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Clinical Sciences,Institute of Biomedicine, Department of Infectious Medicine
(författare)
Early acquisition of herpes simplex virus type 1 antibodies in children--a longitudinal serological study.
- Artikel/kapitelEngelska2007
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LIBRIS-ID:oai:gup.ub.gu.se/56675
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https://gup.ub.gu.se/publication/56675URI
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https://doi.org/10.1016/j.jcv.2007.06.002DOI
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BACKGROUND: Herpes simplex virus type 1 (HSV-1) infections are commonly acquired in childhood, asymptomatically or as a symptomatic infection. However, little is known about the time of HSV seroconversion during infancy and early childhood. OBJECTIVE: To investigate the acquisition of IgG-antibodies to HSV in infants and children. STUDY DESIGN: A longitudinal study, using type-specific HSV-1 and herpes simplex virus type 2 (HSV-2) enzyme-linked immunosorbent assays on sera collected from the mother and from their child at the age of 3, 5, 6, 12, 13 and 30 months. RESULTS: The maternal seroprevalences for HSV-1 was 65% and for HSV-2 19%. A gradual loss of maternal antibodies was seen, with few infants having detectable HSV-1 antibodies at the age of 1 year. A more rapid decline was registered for HSV-2 antibodies. A small number of new HSV-1 infections occurred in 3-5-month olds and more than half of the new infections were detected before the age of 13 months. At the age of 30 months, 30% of the children were HSV-1 antibody positive. CONCLUSION: Seroconversion to HSV-1 commonly occurs already during infancy, suggesting that HSV-1 is transmitted primarily from parent to child.
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Bergström, Tomas,1950Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xberto
(författare)
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Claesson, Bo A,1948Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xclabo
(författare)
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Carlsson, Rose-Marie
(författare)
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Löwhagen, Gun-Britt,1942Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xlowgu
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
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Ingår i:Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology: Elsevier BV40:1, s. 26-301386-6532
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