Association between the estrogen receptor beta gene and age of onset of Parkinson's disease.

• The purpose of this study was to investigate the potential contribution of genetic variants in the estrogen receptor beta gene to the aetiology of Parkinson's disease (PD). Several lines of evidence from human and animal studies suggest a protective role for estrogen in PD. Recently the estrogen receptor beta subtype was reported to be an important mediator of estrogen actions in the nigrostriatal dopamine system. Two single nucleotide polymorphisms at position 1730 and 1082 in the ER beta gene were genotyped, using pyrosequencing, in 260 patients with PD and 308 controls recruited from the Swedish population. Neither of the two estrogen receptor beta polymorphisms was associated with an increased risk for PD. However, the G allele of the A1730G polymorphism was more frequent in patients with an early age of onset than in patients with a late age of onset of PD (P = 0.006). Patients carrying the GG genotype had an odds ratio of 2.2 for having an early onset of PD compared to non-carriers. In conclusion, our results indicate that genetic variation in the estrogen receptor beta gene may influence the age of onset of PD.

Nyckelord

Adult

Age of Onset

Aged

Case-Control Studies

Chi-Square Distribution

Chromosomes

Human

Pair 14

genetics

Estrogen Receptor beta

Female

Gene Frequency

Genetic Predisposition to Disease

Humans

Male

Middle Aged

Odds Ratio

Parkinson Disease

epidemiology

genetics

Polymorphism

Single Nucleotide

genetics

Receptors

Estrogen

genetics

Sweden

epidemiology

Chromosomes

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)