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Staphylococcus aure...
Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database.
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Miro, J M (författare)
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Anguera, Ignasi (författare)
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Cabell, Cristopher H (författare)
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Chen, Anita Y (författare)
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Stafford, Judith A (författare)
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Corey, G R (författare)
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- Olaison, Lars, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
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Eykyn, S (författare)
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Hoen, B (författare)
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Abrutyn, E (författare)
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Raoult, Didier (författare)
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Bayer, Arnold (författare)
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Fowler, V G (författare)
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(creator_code:org_t)
- Oxford University Press (OUP), 2005
- 2005
- Engelska.
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Ingår i: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. - : Oxford University Press (OUP). - 1537-6591. ; 41:4, s. 507-14
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: Staphylococcus aureus native valve infective endocarditis (SA-NVIE) is not completely understood. The objective of this investigation was to describe the characteristics of a large, international cohort of patients with SA-NVIE. METHODS: The International Collaboration on Endocarditis Merged Database (ICE-MD) is a combination of 7 existing electronic databases from 5 countries that contains data on 2212 cases of definite infective endocarditis (IE). RESULTS: Of patients with native valve IE, 566 patients [corrected] had IE due to S. aureus, and 1074 patients had IE due to pathogens other than S. aureus (non-SA-NVIE). Patients with S. aureus IE were more likely to die (20% vs. 12%; P < .001), to experience an embolic event (61% [corrected] vs. 31%; P < .001), or to have a central nervous system event (21% [corrected] vs. 13%; P < .001) and were less likely to undergo surgery (26% vs. 39%; P < .001) than were patients with non-SA-NVIE. Multivariate analysis of prognostic factors of mortality identified age (odds ratio [OR], 1.4; 95% confidence interval [CI], 1.1-1.7), periannular abscess (OR, 2.4; 95% CI, 1.0 [corrected] -5.6), heart failure (OR, 3.9; 95% CI, 2.3-6.7), and absence of surgical therapy (OR, 2.3; 95% CI, 1.3-4.2) as variables that were independently associated with mortality in patients with SA-NVIE. After adjusting for patient-, pathogen-, and treatment-specific characteristics by multivariate analysis, geographical region was also found to be associated with mortality in patients with SA-NVIE (P < .001). CONCLUSIONS: S. aureus is an important and common cause of IE. The outcome of SA-NVIE is worse than that of non-SA-NVIE. Several clinical parameters are independently associated with mortality for patients with SA-NVIE. The clinical characteristics and outcome of SA-NVIE vary significantly by geographic region, although the reasons for such regional variations in outcomes of SA-NVIE are unknown and are probably multifactorial. A large, prospective, multinational cohort study of patients with IE is now under way to further investigate these observations.
Nyckelord
- Databases
- Endocarditis
- Bacterial
- epidemiology
- microbiology
- Humans
- Methicillin Resistance
- Prognosis
- Risk Factors
- Staphylococcal Infections
- epidemiology
- Staphylococcus aureus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Miro, J M
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Anguera, Ignasi
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Cabell, Cristoph ...
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Chen, Anita Y
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Stafford, Judith ...
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Corey, G R
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visa fler...
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Olaison, Lars, 1 ...
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Eykyn, S
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Hoen, B
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Abrutyn, E
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Raoult, Didier
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Bayer, Arnold
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Fowler, V G
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visa färre...
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Clinical infecti ...
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Clinical Infecti ...
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Göteborgs universitet