Search: WFRF:(Arnold H.)
> (2005-2009) >
Staphylococcus aure...
Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database.
-
Miro, J M (author)
-
Anguera, Ignasi (author)
-
Cabell, Cristopher H (author)
-
show more...
-
Chen, Anita Y (author)
-
Stafford, Judith A (author)
-
Corey, G R (author)
-
- Olaison, Lars, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar,Institute of Internal Medicine, Dept of Infectious Diseases
-
Eykyn, S (author)
-
Hoen, B (author)
-
Abrutyn, E (author)
-
Raoult, Didier (author)
-
Bayer, Arnold (author)
-
Fowler, V G (author)
-
show less...
-
(creator_code:org_t)
- Oxford University Press (OUP), 2005
- 2005
- English.
-
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. - : Oxford University Press (OUP). - 1537-6591. ; 41:4, s. 507-14
- Related links:
-
https://academic.oup...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Staphylococcus aureus native valve infective endocarditis (SA-NVIE) is not completely understood. The objective of this investigation was to describe the characteristics of a large, international cohort of patients with SA-NVIE. METHODS: The International Collaboration on Endocarditis Merged Database (ICE-MD) is a combination of 7 existing electronic databases from 5 countries that contains data on 2212 cases of definite infective endocarditis (IE). RESULTS: Of patients with native valve IE, 566 patients [corrected] had IE due to S. aureus, and 1074 patients had IE due to pathogens other than S. aureus (non-SA-NVIE). Patients with S. aureus IE were more likely to die (20% vs. 12%; P < .001), to experience an embolic event (61% [corrected] vs. 31%; P < .001), or to have a central nervous system event (21% [corrected] vs. 13%; P < .001) and were less likely to undergo surgery (26% vs. 39%; P < .001) than were patients with non-SA-NVIE. Multivariate analysis of prognostic factors of mortality identified age (odds ratio [OR], 1.4; 95% confidence interval [CI], 1.1-1.7), periannular abscess (OR, 2.4; 95% CI, 1.0 [corrected] -5.6), heart failure (OR, 3.9; 95% CI, 2.3-6.7), and absence of surgical therapy (OR, 2.3; 95% CI, 1.3-4.2) as variables that were independently associated with mortality in patients with SA-NVIE. After adjusting for patient-, pathogen-, and treatment-specific characteristics by multivariate analysis, geographical region was also found to be associated with mortality in patients with SA-NVIE (P < .001). CONCLUSIONS: S. aureus is an important and common cause of IE. The outcome of SA-NVIE is worse than that of non-SA-NVIE. Several clinical parameters are independently associated with mortality for patients with SA-NVIE. The clinical characteristics and outcome of SA-NVIE vary significantly by geographic region, although the reasons for such regional variations in outcomes of SA-NVIE are unknown and are probably multifactorial. A large, prospective, multinational cohort study of patients with IE is now under way to further investigate these observations.
Keyword
- Databases
- Endocarditis
- Bacterial
- epidemiology
- microbiology
- Humans
- Methicillin Resistance
- Prognosis
- Risk Factors
- Staphylococcal Infections
- epidemiology
- Staphylococcus aureus
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Miro, J M
-
Anguera, Ignasi
-
Cabell, Cristoph ...
-
Chen, Anita Y
-
Stafford, Judith ...
-
Corey, G R
-
show more...
-
Olaison, Lars, 1 ...
-
Eykyn, S
-
Hoen, B
-
Abrutyn, E
-
Raoult, Didier
-
Bayer, Arnold
-
Fowler, V G
-
show less...
- Articles in the publication
-
Clinical infecti ...
-
Clinical Infecti ...
- By the university
-
University of Gothenburg