Variation in FTO contributes to childhood obesity and severe adult obesity.

• We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

Keyword

Adiposity

Adult

Age of Onset

Body Composition

Body Mass Index

Case-Control Studies

Child

Chromosomes

Human

Pair 16

genetics

Cohort Studies

Europe

Female

Genetic Predisposition to Disease

Humans

Introns

genetics

Male

Middle Aged

Obesity

genetics

Polymorphism

Single Nucleotide

genetics

Variation (Genetics)

genetics

Publication and Content Type

ref (subject category)

art (subject category)