Elevated cerebrospinal fluid neurofilament light protein concentrations predict the development of AIDS dementia complex.

• The light subunit of neurofilament protein (NFL) is a sensitive indicator of central nervous system axonal injury. We retrospectively identified 9 subjects participating in a longitudinal cohort study who developed acquired immunodeficiency syndrome dementia complex (ADC) and who had had a lumbar puncture performed within 2 years before presentation. Elevated cerebrospinal fluid (CSF) NFL concentrations were found in 7 (78%) of the 9 case patients who later developed ADC, compared with 9 (33%) of 27 CD4 cell count-matched HIV-1-infected control subjects. By contrast, no differences were found in CSF HIV-1 RNA or neopterin concentrations between the 2 groups. CSF NFL may prove to be a useful predictive marker for ADC.

Nyckelord

AIDS Dementia Complex

diagnosis

etiology

physiopathology

Biological Markers

cerebrospinal fluid

Cohort Studies

Female

HIV Infections

complications

physiopathology

HIV-1

genetics

Humans

Longitudinal Studies

Male

Middle Aged

Neopterin

cerebrospinal fluid

Neurofilament Proteins

cerebrospinal fluid

Predictive Value of Tests

RNA

Viral

blood

cerebrospinal fluid

Retrospective Studies

Time Factors

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)