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Clinical and bacter...
Clinical and bacteriologic efficacy of telithromycin in patients with bacteremic community-acquired pneumonia.
- Artikel/kapitelEngelska2006
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LIBRIS-ID:oai:gup.ub.gu.se/58599
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https://gup.ub.gu.se/publication/58599URI
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https://doi.org/10.1016/j.rmed.2005.11.007DOI
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Ämneskategori:art swepub-publicationtype
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This retrospective analysis was performed to determine the clinical and bacteriologic efficacy of the ketolide antibacterial telithromycin in patients with community-acquired pneumonia (CAP) with pneumococcal bacteremia. Patients 13 years old with radiologically confirmed CAP and a positive blood culture for Streptococcus pneumoniae at screening were analyzed from eight multicenter Phase III/IV clinical trials. In four open-label, non-comparative studies, patients received telithromycin 800 mg once daily for 7-10 days. In four randomized, controlled, double-blind, comparative studies, patients received telithromycin 800 mg once daily for 5-10 days or a comparator antimicrobial (amoxicillin 1000 mg three times daily, clarithromycin 500 mg twice daily, or trovafloxacin 200 mg once daily) for 7-10 days. In total, 118 patients (telithromycin, 94/1061 [8.9%]; comparator, 24/244 [9.8%]) had documented pneumococcal bacteremia. Those who were treated with telithromycin achieved a clinical cure rate of 90.2% (74/82, per-protocol population); S. pneumoniae was eradicated in 77/82 (93.9%) bacteremic patients who received telithromycin and 15/19 (78.9%) comparator-treated patients. Clinical cure was also observed among telithromycin-treated bacteremic patients who were infected with penicillin- or erythromycin-resistant strains of S. pneumoniae (5/7 and 8/10, respectively). In conclusion, telithromycin achieves high clinical and bacteriologic cure rates in CAP patients with pneumococcal bacteremia.
Ämnesord och genrebeteckningar
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Adolescent
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Adult
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Aged
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Anti-Bacterial Agents
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administration & dosage
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therapeutic use
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Clinical Trials
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Phase IV
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Community-Acquired Infections
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drug therapy
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microbiology
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Female
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Humans
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Ketolides
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administration & dosage
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therapeutic use
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Male
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Meta-Analysis
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Middle Aged
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Multicenter Studies
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Pneumonia
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Bacterial
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drug therapy
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microbiology
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Randomized Controlled Trials
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Retrospective Studies
Biuppslag (personer, institutioner, konferenser, titlar ...)
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van Rensburg, D
(författare)
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Hagberg, Lars,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xhagbl
(författare)
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Fogarty, C
(författare)
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Tellier, G
(författare)
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Rangaraju, M
(författare)
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Nusrat, R
(författare)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Respiratory medicine: Elsevier BV100:4, s. 577-850954-6111
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