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The endocannabinoid...
The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells
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Aguado, T (author)
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Palazuelos, J (author)
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Monory, K (author)
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Stella, N (author)
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Cravatt, B (author)
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Lutz, B (author)
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Marsicano, G (author)
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- Kokaia, Zaal (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Guzman, M (author)
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Galve-Roperh, I (author)
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: The Journal of Neuroscience. - 1529-2401. ; 26:5, s. 1551-1561
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival. The function of the endocannabinoid system has been extensively studied in differentiated neurons, but its potential role in neural progenitor cells remains to be elucidated. Here we show that the CB1 receptor and the endocannabinoid-inactivating enzyme fatty acid amide hydrolase are expressed, both in vitro and in vivo, in postnatal radial glia (RC2(+) cells) and in adult nestin type I (nestin (+)GFAP(+)) neural progenitor cells. Cell culture experiments show that CB1 receptor activation increases progenitor proliferation and differentiation into astroglial cells in vitro. In vivo analysis evidences that, in postnatal CB1-/- mouse brain, progenitor proliferation and astrogliogenesis are impaired. Likewise, in adult CB1-deficient mice, neural progenitor proliferation is decreased but is increased in fatty acid amide hydrolase-deficient mice. In addition, endocannabinoid signaling controls neural progenitor differentiation in the adult brain by promoting astroglial differentiation of newly born cells. These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- glia
- CB1 receptor
- radial
- astrogliogenesis
- proliferation
- cannabinoid
- neural progenitor
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Aguado, T
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Palazuelos, J
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Monory, K
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Stella, N
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Cravatt, B
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Lutz, B
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show more...
-
Marsicano, G
-
Kokaia, Zaal
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Guzman, M
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Galve-Roperh, I
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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The Journal of N ...
- By the university
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Lund University