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Differential CSF bi...
Differential CSF biomarker levels in APOE-epsilon4-positive and -negative patients with memory impairment.
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- Andersson, Christin (author)
- Karolinska Institutet
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Johansson, Sven-Erik (author)
- Karolinska Institutet
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- Almkvist, Ove (author)
- Karolinska Institutet
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- Engfeldt, Peter (author)
- Örebro universitet,Hälsoakademin
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- Lindau, Maria (author)
- Stockholms universitet,Uppsala universitet,Geriatrik,Psykologiska institutionen
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- Eriksdotter-Jönhagen, Maria (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2006-11-22
- 2007
- English.
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In: Dementia and geriatric cognitive disorders. - Basel : S. Karger AG. - 1420-8008 .- 1421-9824. ; 23:2, s. 87-95
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Abstract
Subject headings
Close
- OBJECTIVES: To investigate the relationships between episodic memory, APOE genotype, CSF markers (total tau, T-tau; phospho-tau, P-tau; beta-amyloid, Abeta42) and longitudinal cognitive decline. METHODS: 124 memory clinic patients were retrospectively divided into 6 groups based on (i) episodic memory function (Rey Auditory Verbal Learning Test, RAVLT): severe, moderate or no impairment (SIM, MIM or NIM), and (ii) APOE genotype (epsilon4+ or epsilon4-). CSF marker levels and cognitive decline were compared across groups. RESULTS: Episodic memory function, according to RAVLT scores, was significantly correlated with CSF marker levels only among epsilon4+ subjects and not among epsilon4- subjects. When comparing the 6 subgroups, SIM epsilon4+ and MIM epsilon4+ groups showed significantly lower Abeta42 levels than the other groups. T-tau and P-tau levels were significantly increased in SIM epsilon4+ when compared to all the other groups, including the SIM epsilon4- group. However, both SIM epsilon4+ and SIM epsilon4- declined cognitively during the follow-up. CONCLUSION: It remains to be determined whether APOE genotype affects the expression of biomarkers in CSF, or whether the different biomarker patterns reflect different types of disease processes in patients with progressive cognitive dysfunction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Amyloid beta-Protein Precursor
- cerebrospinal fluid
- Apolipoprotein E4
- genetics
- Apolipoproteins E
- genetics
- Biological Markers
- cerebrospinal fluid
- Cognition Disorders
- cerebrospinal fluid
- diagnosis
- genetics
- Female
- Genotype
- Humans
- Male
- Memory Disorders
- cerebrospinal fluid
- diagnosis
- genetics
- Middle Aged
- Neuropsychological Tests
- Prevalence
- Retrospective Studies
- Severity of Illness Index
- tau Proteins
- cerebrospinal fluid
- MEDICINE
- Geriatrics and medical gerontology
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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