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Search: WFRF:(Behboudi Afrouz 1967) > (2001-2004) > Altered Notch signa...

  • Enlund, Fredrik,1968Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology,Department of Pathology, Lundberg Laboratory for Cancer Research, Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden (author)

Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.

  • Article/chapterEnglish2004

Publisher, publication year, extent ...

  • Elsevier BV,2004

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/58759
  • https://gup.ub.gu.se/publication/58759URI
  • https://doi.org/10.1016/j.yexcr.2003.09.007DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1936136URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-22538URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We thank Eva Röijer for FISH mapping of YAC clones, Barbro Wedell, Helene Sjögren, and Fredrik Persson for cytogenetic and spectral karyotype analyses of tumors, and Ulric Pedersen for assistance in preparing figures. This work was supported by grants from the Swedish Cancer Society, the IngaBritt and Arne Lundberg Research Foundation, and the Sahlgrenska University Hospital Foundations.
  • Chromosome translocations in neoplasia commonly result in fusion genes that may encode either novel fusion proteins or normal, but ectopically expressed proteins. Here we report the cloning of a novel fusion gene in a common type of salivary and bronchial gland tumor, mucoepidermoid carcinomas (MEC), as well as in benign Warthin's tumors (WATs). The fusion, which results from a t(11;19)(q21-22;p13) translocation, creates a chimeric gene in which exon 1 of a novel gene of unknown function, designated WAMTP1, is linked to exons 2-5 of the recently identified Mastermind-like Notch coactivator MAML2. In the fusion protein, the N-terminal basic domain of MAML2, which is required for binding to intracellular Notch (Notch ICD), is replaced by an unrelated N-terminal sequence from WAMTP1. Mutation analysis of the N-terminus of WAMTP1-MAML2 identified two regions of importance for nuclear localization (amino acids 11-20) and for colocalization with MAML2 and Notch1 ICD in nuclear granules (amino acids 21-42). Analyses of the Notch target genes HES5 and MASH1 in MEC tumors with and without the WAMTP1-MAML2 fusion revealed upregulation of HES5 and downregulation of MASH1 in fusion positive MECs compared to normal salivary gland tissue and MECs lacking the fusion. These findings suggest that altered Notch signaling plays an important role in the genesis of benign and malignant neoplasms of salivary and bronchial gland origin.

Subject headings and genre

  • MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
  • MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
  • Adenolymphoma
  • metabolism
  • Animals
  • Artificial Gene Fusion
  • COS Cells
  • Carcinoma
  • Mucoepidermoid
  • genetics
  • metabolism
  • Cell Line
  • Tumor
  • Cercopithecus aethiops
  • Chromosome Mapping
  • Chromosomes
  • Human
  • Pair 11
  • Chromosomes
  • Human
  • Pair 19
  • Cloning
  • Molecular
  • Exons
  • Gene Deletion
  • Gene Expression Regulation
  • Neoplastic
  • Green Fluorescent Proteins
  • Humans
  • Karyotyping
  • Luminescent Proteins
  • metabolism
  • Membrane Proteins
  • metabolism
  • Receptors
  • Notch
  • Salivary Gland Neoplasms
  • genetics
  • metabolism
  • Signal Transduction
  • Translocation
  • Genetic
  • Mucoepidermoid carcinoma

Added entries (persons, corporate bodies, meetings, titles ...)

  • Behboudi, Afrouz,1967Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology,Department of Pathology, Lundberg Laboratory for Cancer Research, Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:his)beha (author)
  • Andrén, Ywonne,1956Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology,Department of Pathology, Lundberg Laboratory for Cancer Research, Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:gu)xandyw (author)
  • Öberg, CamillaDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)
  • Lendahl, UrbanKarolinska Institutet,Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)
  • Mark, JoachimGothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology,Department of Pathology, Lundberg Laboratory for Cancer Research, Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden (author)
  • Stenman, Göran,1953Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology,Department of Pathology, Lundberg Laboratory for Cancer Research, Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden(Swepub:gu)xsteng (author)
  • Göteborgs universitetInstitutionen för laboratoriemedicin , Avdelningen för patologi (creator_code:org_t)

Related titles

  • In:Experimental cell research: Elsevier BV292:1, s. 21-80014-48271090-2422

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