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Search: id:"swepub:oai:gup.ub.gu.se/59549" > Bovine growth hormo...

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  • Olsson, Bob,1969Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism (author)

Bovine growth hormone transgenic mice are resistant to diet-induced obesity but develop hyperphagia, dyslipidemia, and diabetes on a high-fat diet

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • The Endocrine Society,2005

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/59549
  • https://gup.ub.gu.se/publication/59549URI
  • https://doi.org/10.1210/en.2004-1232DOI
  • https://lup.lub.lu.se/record/255349URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • It is known that bovine GH (bGH) transgenic mice have increased body mass, insulin resistance, and altered lipoprotein metabolism when fed a normal diet (ND). In this study, the effects of 8 wk of high-fat diet (HFD) were investigated in 6-month-old male bGH mice. Although littermate controls had unchanged energy intake, energy intake was higher in the bGH mice on a HFD than on a low-fat diet. Nevertheless, the bGH mice were resistant to diet-induced weight gain, and only in the bGH mice did the HFD result in increased energy expenditure. Glucose oxidation was higher in the bGH mice compared with littermate controls on both a HFD and ND. In addition, the bGH mice had 0.5 C higher body temperature throughout the day and increased hepatic uncoupling protein 2 expression; changes that were unaffected by the HFD. On a HFD, the effect of bGH overexpression on serum triglycerides and apolipoprotein B was opposite to that on a ND, resulting in higher serum concentrations of triglycerides and apolipoprotein B compared with littermate controls. Increased serum triglycerides were explained by decreased triglyceride clearance. The HFD led to diabetes only in the bGH mice. In conclusion, bGH transgenic mice were resistant to diet-induced obesity despite hyperphagia, possibly due to increased energy expenditure. On a HFD, bGH mice became dyslipidemic and diabetic and thereby more accurately reflect the metabolic situation in acromegalic patients.

Subject headings and genre

  • MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
  • MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
  • Acromegaly/metabolism/physiopathology
  • Animals
  • Body Composition
  • Body Temperature
  • Carrier Proteins/genetics
  • Cattle
  • Diabetes Mellitus
  • Experimental/metabolism/*physiopathology
  • Dietary Fats/pharmacology
  • Eating
  • Energy Metabolism/physiology
  • Glucose Tolerance Test
  • Growth Hormone/*genetics
  • Hyperlipidemias/metabolism/*physiopathology
  • Hyperphagia/metabolism/*physiopathology
  • Ion Channels
  • Lipids/blood
  • Lipoproteins/blood
  • Membrane Proteins/genetics
  • Membrane Transport Proteins/genetics
  • Mice
  • Mice
  • Transgenic
  • Mitochondrial Proteins/genetics
  • Obesity/metabolism/*physiopathology
  • Oxygen Consumption/physiology

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bohlooly-Yeganeh, Mohammad,1966Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xbohmo (author)
  • Fitzgerald, Sharyn M.Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology (author)
  • Frick, Fredrik,1973Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry (author)
  • Ljungberg, Anna,1977Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xljuan (author)
  • Ahrén, BoLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-bah (author)
  • Törnell, Jan,1960Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xtornj (author)
  • Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xbgort (author)
  • Oscarsson, Jan,1960Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xoscja (author)
  • Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism (creator_code:org_t)

Related titles

  • In:Endocrinology: The Endocrine Society146:2, s. 920-300013-72271945-7170

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