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Haemodynamically si...
Abstract
Ämnesord
Stäng
- Flow-mediated vasodilation is suggested as one of the mechanisms involved in arterial expansive remodelling, which is thought to be a defence mechanism in atherogenesis. In the present study, we tested the hypothesis that lumen obstructive plaque formation is associated with failure of NO (nitric oxide)-dependent vasodilation in conduit vessels. Cardiac function and aortic root flow velocities were assessed using high-resolution echocardiography and two-dimensional-guided pulsed Doppler in ApoE(-/-) (apolipoprotein E-deficient) mice fed a standard or high-cholesterol diet. Endothelial function in the proximal and mid-descending aortic regions was studied using a myograph technique. Flow velocity at the aortic root of cholesterol-fed ApoE(-/-) mice was significantly increased as a result of lumen narrowing, detected via histological analysis. NO-dependent vasodilatory responses were selectively impaired in the atherosclerosis-prone vascular regions in cholesterol-fed ApoE(-/-) mice. In conclusion, consumption of a high-cholesterol diet results in lumen obstructive plaque formation in ApoE(-/-) mice, which significantly alters aortic root haemodynamics. This phenomenon is associated with impaired NO-dependent vasodilation in vessel segments known to be prone to atherosclerosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Acetylcholine/pharmacology
- Animals
- Aorta
- Apolipoproteins E/*genetics
- Arteries
- Arteriosclerosis/*etiology/physiopathology/ultrasonography
- Blood Pressure
- Cholesterol
- Dietary/*administration & dosage
- Coronary Vessels/metabolism
- Echocardiography
- Doppler
- Pulsed
- Endothelium
- Vascular/*physiopathology
- Female
- Image Processing
- Computer-Assisted
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Nitroprusside/pharmacology
- Random Allocation
- Vasodilator Agents/pharmacology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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