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Increased serum-GFA...
Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome
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Nylen, K (author)
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- Öst, Martin, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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- Csajbok, Ludvig Z, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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- Nilsson, Inger (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Blennow, Kaj, 1958 (author)
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- Nellgård, Bengt, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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Rosengren, Lars, 1954 (author)
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: J Neurol Sci. - : Elsevier BV. - 0022-510X. ; 240:1-2, s. 85-91
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVES: Several studies have established the relevance of S-100 in blood as a marker of brain damage after traumatic brain injury. However, a more specific marker is required and glial fibrillary acidic protein (GFAP) is considered to be a good candidate. METHODS: In order to assess the increase of GFAP in serum (s-GFAP) after a severe traumatic brain injury (TBI) we collected daily serum samples from 59 patients with severe TBI starting on the day of the trauma. S-GFAP was measured using a sandwich ELISA. The Glasgow outcome scale (GOS) assessed outcome after 1 year. RESULTS: All but one patient had maximal s-GFAP values above the laboratory reference value (median increased 10-fold). The highest detected levels were seen during the first days after TBI and then decreased gradually. Patients with unfavourable outcome had significantly (p<0.001) higher maximal s-GFAP values in the acute phase compared with patients with favourable outcome. All patients (n=5) with s-GFAP>15.04 microg /L died (reference level<0.15 microg/L). We found no significant difference in the maximal s-GFAP levels of patients with isolated brain injury in comparison with patients with multiple traumas. CONCLUSION: Serum-GFAP is increased during the first days after a severe traumatic brain injury and related to clinical outcome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Aged
- 80 and over
- Brain Injuries/*blood
- Child
- Enzyme-Linked Immunosorbent Assay/methods
- Evaluation Studies
- Female
- Glasgow Coma Scale
- Glasgow Outcome Scale
- Glial Fibrillary Acidic Protein/*blood
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Prospective Studies
- Reference Values
- Retrospective Studies
- Sensitivity and Specificity
- Time Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nylen, K
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Öst, Martin, 196 ...
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Csajbok, Ludvig ...
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Nilsson, Inger
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Blennow, Kaj, 19 ...
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Nellgård, Bengt, ...
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Rosengren, Lars, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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J Neurol Sci
- By the university
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University of Gothenburg