Left ventricular diastolic dysfunction late after aortic valve replacement in patients with aortic stenosis

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Gjertsson, Peter,1961Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute (författare)

Left ventricular diastolic dysfunction late after aortic valve replacement in patients with aortic stenosis

Artikel/kapitelEngelska2005

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Elsevier BV,2005

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LIBRIS-ID:oai:gup.ub.gu.se/59784
https://gup.ub.gu.se/publication/59784URI
https://doi.org/10.1016/j.amjcard.2005.04.052DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:1951507URI

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Språk:engelska

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Patients with severe aortic stenosis (AS) are known to have increased left ventricular (LV) mass and diastolic dysfunction. It has been suggested that LV mass and diastolic function normalize after aortic valve replacement (AVR). In the present study, change in LV mass index and diastolic function 10 years after AVR for AS was evaluated. Patients who underwent AVR from 1991 to 1993 (n = 57; mean age 67 +/- 8.6 years at AVR, 58% men) were investigated with Doppler echocardiography preoperatively and 2 and 10 years postoperatively. Diastolic function was evaluated by integrating mitral and pulmonary venous flow data. Expected values for each patient, taking age into consideration, were defined using a control group (n = 71; age range 18 to 83 years). Patients were classified into 4 types: normal diastolic function (type A), mild diastolic dysfunction (type B), moderate diastolic dysfunction (type C), and severe diastolic dysfunction (type D). There was a reduction in LV mass index between the preoperative (161 +/- 39 g/m2) and 2-year follow-up (114 +/- 28 g/m2) examinations (p <0.0001), but no further reduction was seen at 10 years (119 +/- 49 g/m2). The percentage of patients with increased LV mass index decreased from 83% preoperatively to 29% at 2-year follow-up (p <0.001). The percentage of patients with moderate to severe LV diastolic dysfunction (types C and D) was unchanged between the preoperative (7%) and 2-year follow-up (13%) examinations (p = 0.27). The percentage of patients increased at 10-year follow-up to 61% (p <0.0001). In conclusion, this reveals the development of moderate to severe diastolic dysfunction 10 years after AVR, despite a reduction in the LV mass index.

Ämnesord och genrebeteckningar

Adult
Age Distribution
Aged
Aged
80 and over
Aortic Valve Stenosis/*surgery
Echocardiography
Doppler
Female
Follow-Up Studies
Heart Valve Prosthesis Implantation/*adverse effects
Humans
Male
Middle Aged
Myocardial Contraction
Postoperative Complications
Retrospective Studies
Sex Distribution
Time Factors
Ventricular Dysfunction
Left/*etiology/physiopathology/ultrasonography
Ventricular Function
Left/physiology

Biuppslag (personer, institutioner, konferenser, titlar ...)

Caidahl, Kenneth,1949Karolinska Institutet,Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xcaike (författare)
Bech-Hanssen, Odd,1956Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xbecod (författare)
Göteborgs universitetHjärt-kärlinstitutionen (creator_code:org_t)

Sammanhörande titlar

Ingår i:Am J Cardiol: Elsevier BV96:5, s. 722-70002-9149

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Av författaren/redakt...: Gjertsson, Peter ...; Caidahl, Kenneth ...; Bech-Hanssen, Od ...

Artiklar i publikationen: Am J Cardiol

Av lärosätet: Göteborgs universitet; Karolinska Institutet

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