Search: id:"swepub:oai:gup.ub.gu.se/60167" >
Beneficial effect o...
Beneficial effect of angiotensin-converting enzyme inhibitor on dilated cardiomyopathy induced by autoimmune mechanism against beta1-adrenoceptor.
- Article/chapterEnglish2000
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/60167
-
https://gup.ub.gu.se/publication/60167URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
We have shown that a peptide corresponding to the sequence of the second extracellular loop of the human beta1-adrenoceptor (beta1-peptide) was able to induce an autoimmune cardiomyopathy in rabbits. In this study, we examined the effect of angiotensin-converting enzyme inhibitor (ACEI) on beta1-peptide-induced cardiomyopathy. Rabbits were divided into four groups: (1) control group (n= 6) receiving saline injection; (2) beta1-peptide group (n = 8) immunized with beta1-peptide; (3) ACEI group (n = 6), lisinopril (3 mg/day) given orally and receiving saline injection; and (4) ACEI + beta1-peptide group (n = 7), lisinopril (3 mg/day) given orally and immunized with beta1-peptide. Our results showed that, after 1 year, all rabbits in the beta1-peptide group had an increase in heart weight, wall thinning and dilatations of both ventricles as compared with rabbits in the ACEI + beta1-peptide group that had normal heart weight and shape. All rabbits in the beta1-peptide group exhibited multifocal degeneration and necrosis of myocardial cells with moderate infiltration of inflammatory cells. In the ACEI + beta1-peptide group, three rabbits showed focal degeneration and necrosis of myocardial cells accompanied by mononuclear cells. The lesions in this group were apparently less marked than those in the beta1-peptide group. In conclusion, ACEI protects the myocardium from injury induced by an autoimmune mechanism against beta1-adrenoceptor.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Fu, Michael,1963Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Wallenberglaboratoriet,Institute of Internal Medicine,Wallenberg Laboratory(Swepub:gu)xfumiw
(author)
-
Hayase, M
(author)
-
Katsuda, T
(author)
-
Yamaguchi, N
(author)
-
Teraoka, K
(author)
-
Kurihara, T
(author)
-
Takekoshi, N
(author)
-
Wakabayashi, H
(author)
-
Göteborgs universitetInstitutionen för invärtesmedicin
(creator_code:org_t)
Related titles
-
In:Journal of cardiovascular pharmacology36 Suppl 20160-2446
Internet link
Find in a library
To the university's database
- By the author/editor
-
Matsui, S
-
Fu, Michael, 196 ...
-
Hayase, M
-
Katsuda, T
-
Yamaguchi, N
-
Teraoka, K
-
show more...
-
Kurihara, T
-
Takekoshi, N
-
Wakabayashi, H
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Physiology
- Articles in the publication
-
Journal of cardi ...
- By the university
-
University of Gothenburg