Search: WFRF:(Müller Esterl W) >
Autoantibodies agai...
Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension.
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- Fu, Michael, 1963 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för invärtesmedicin,Wallenberg Laboratory,Institute of Internal Medicine
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- Herlitz, Hans, 1946 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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Schulze, W (author)
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Wallukat, G (author)
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Micke, P (author)
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Eftekhari, Pierre (author)
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- Sjögren, Klas-Göran (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Hjalmarson, Åke, 1937 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Müller-Esterl, W (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Hoebeke, Johan (author)
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: Journal of hypertension. - 0263-6352. ; 18:7, s. 945-53
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- Sera from patients with malignant essential hypertension (n = 14), malignant secondary hypertension mainly attributable to renovascular diseases (n = 12) and renovascular diseases without malignant hypertension (n = 11) and from normotensive healthy blood donors (n = 35) were studied for the presence of autoantibodies against G-protein-coupled cardiovascular receptors. Autoantibodies against the angiotensin II receptor (AT1) were detected in 14, 33, 18 and 14% of patients with malignant essential hypertension, malignant secondary hypertension, renovascular diseases and control patients, respectively. Sensitivity of the enzyme immunoassay was assessed as 5 microg/ml IgG. Patients did not show antibodies against bradykinin (B2) or angiotensin II subtype 2 (AT2) receptors. Autoantibodies affinity-purified from positive patients localized AT receptors in Chinese hamster ovary transfected cells, and displayed a positive chronotropic effect on cultured neonatal rat cardiomyocytes. These results demonstrate the existence of autoantibodies against a functional extracellular domain of human AT1 receptors in patients with malignant hypertension, and suggest that these autoantibodies might be involved in the pathogenesis of malignant hypertension.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Animals
- Autoantibodies
- immunology
- Biological Markers
- blood
- Cells
- Cultured
- Cricetinae
- Enzyme-Linked Immunosorbent Assay
- Female
- Heart Ventricles
- embryology
- immunology
- metabolism
- Humans
- Hypertension
- Malignant
- blood
- immunology
- Hypertension
- Renal
- blood
- immunology
- Immunoglobulin G
- immunology
- Kidney Cortex
- cytology
- immunology
- metabolism
- Male
- Middle Aged
- Ovary
- cytology
- immunology
- metabolism
- Rats
- Receptor
- Angiotensin
- Type 1
- Receptors
- Angiotensin
- blood
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Fu, Michael, 196 ...
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Herlitz, Hans, 1 ...
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Schulze, W
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Wallukat, G
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Micke, P
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Eftekhari, Pierr ...
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show more...
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Sjögren, Klas-Gö ...
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Hjalmarson, Åke, ...
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Müller-Esterl, W
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Hoebeke, Johan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Journal of hyper ...
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University of Gothenburg