Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension.

Fu, Michael,1963Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för invärtesmedicin,Wallenberg Laboratory,Institute of Internal Medicine (author)

Sera from patients with malignant essential hypertension (n = 14), malignant secondary hypertension mainly attributable to renovascular diseases (n = 12) and renovascular diseases without malignant hypertension (n = 11) and from normotensive healthy blood donors (n = 35) were studied for the presence of autoantibodies against G-protein-coupled cardiovascular receptors. Autoantibodies against the angiotensin II receptor (AT1) were detected in 14, 33, 18 and 14% of patients with malignant essential hypertension, malignant secondary hypertension, renovascular diseases and control patients, respectively. Sensitivity of the enzyme immunoassay was assessed as 5 microg/ml IgG. Patients did not show antibodies against bradykinin (B2) or angiotensin II subtype 2 (AT2) receptors. Autoantibodies affinity-purified from positive patients localized AT receptors in Chinese hamster ovary transfected cells, and displayed a positive chronotropic effect on cultured neonatal rat cardiomyocytes. These results demonstrate the existence of autoantibodies against a functional extracellular domain of human AT1 receptors in patients with malignant hypertension, and suggest that these autoantibodies might be involved in the pathogenesis of malignant hypertension.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
Animals
Autoantibodies
immunology
Biological Markers
blood
Cells
Cultured
Cricetinae
Enzyme-Linked Immunosorbent Assay
Female
Heart Ventricles
embryology
immunology
metabolism
Humans
Hypertension
Malignant
blood
immunology
Hypertension
Renal
blood
immunology
Immunoglobulin G
immunology
Kidney Cortex
cytology
immunology
metabolism
Male
Middle Aged
Ovary
cytology
immunology
metabolism
Rats
Receptor
Angiotensin
Type 1
Receptors
Angiotensin
blood
immunology

Herlitz, Hans,1946Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xherha (author)
Schulze, W (author)
Wallukat, G (author)
Micke, P (author)
Eftekhari, Pierre (author)
Sjögren, Klas-GöranGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (author)
Hjalmarson, Åke,1937Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xhjala (author)
Müller-Esterl, WGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory (author)
Hoebeke, Johan (author)
Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

By the author/editor: Fu, Michael, 196 ...; Herlitz, Hans, 1 ...; Schulze, W; Wallukat, G; Micke, P; Eftekhari, Pierr ...; show more...; Sjögren, Klas-Gö ...; Hjalmarson, Åke, ...; Müller-Esterl, W; Hoebeke, Johan; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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